Inflammation is a primary component of both initiation and promotion of colorectal cancer
(CRC). Cytokines secreted by macrophages, including tumor necrosis factor alpha (TNFα) …

Estrogen hormones protect against colorectal cancer (CRC) and a preventative role of
estrogen receptor beta (ERβ) on CRC has been supported using full knockout animals …

Several studies suggest estrogen to be protective against the development of colon cancer.
Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal …

Colorectal cancer (CRC) is the third leading cause of cancer death in the western world. In
women, menopausal hormone therapy has been shown to reduce CRC incidence by 20 …

In normal colon tissue, oestrogen receptor alpha (ERα) is expressed at low levels, while
oestrogen receptor beta (ERβ) is considered the dominant subtype. However, in colon …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Simple Summary Colon cancer is one of the common cancers affecting a large number of
patients globally. In sporadic CRC, several genetic factors may play important roles such as …

Several reports indicate crosstalk between the transcription factor nuclear factor erythroid 2-
related factor 2 (Nrf2) and estrogen, which has a protective effect in colorectal cancer (CRC) …

Inflammation is one of the critical risk factors for colorectal cancer (CRC). However, the
mechanisms for transition from colitis to CRC remain elusive. Recently, epigenetic changes …

Colorectal cancer (CRC) is the predominant cause of cancer-related death worldwide,
because of the lack of effective therapeutic targets. Estrogen-related receptor gamma …