Inner hair cell loss disrupts hearing and cochlear function leading to sensory deprivation and enhanced central auditory gain
There are three times as many outer hair cells (OHC) as inner hair cells (IHC), yet IHC
transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I …
transmit virtually all acoustic information to the brain as they synapse with 90–95% of type I …
Effects of selective inner hair cell loss on auditory nerve fiber threshold, tuning and spontaneous and driven discharge rate
J Wang, NL Powers, P Hofstetter, P Trautwein, D Ding… - Hearing research, 1997 - Elsevier
Current theories assume that the outer hair cells (OHC) are responsible for the sharp tuning
and exquisite sensitivity of the ear whereas inner hair cells (IHC) are mainly responsible for …
and exquisite sensitivity of the ear whereas inner hair cells (IHC) are mainly responsible for …
Selective inner hair cell dysfunction in chinchillas impairs hearing-in-noise in the absence of outer hair cell loss
E Lobarinas, R Salvi, D Ding - Journal of the Association for Research in …, 2016 - Springer
Poorer hearing in the presence of background noise is a significant problem for the hearing
impaired. Ototoxic drugs, ageing, and noise exposure can damage the sensory hair cells of …
impaired. Ototoxic drugs, ageing, and noise exposure can damage the sensory hair cells of …
Inner hair cell loss leads to enhanced response amplitudes in auditory cortex of unanesthetized chinchillas: evidence for increased system gain
Carboplatin preferentially destroys inner hair cells (IHCs) in the chinchilla inner ear, while
retaining a near-normal outer hair cell (OHC) population. The present study investigated the …
retaining a near-normal outer hair cell (OHC) population. The present study investigated the …
A review of the effects of selective inner hair cell lesions on distortion product otoacoustic emissions, cochlear function and auditory evoked potentials
Carboplatin, a second-generation antineoplastic drug, is much less ototoxic than cisplatin in
humans and many laboratory animals. However, when a moderate dose of carboplatin is …
humans and many laboratory animals. However, when a moderate dose of carboplatin is …
Re-emergent inhibition of cochlear inner hair cells in a mouse model of hearing loss
SP Zachary, PA Fuchs - Journal of Neuroscience, 2015 - Soc Neuroscience
Hearing loss among the elderly correlates with diminished social, mental, and physical
health. Age-related cochlear cell death does occur, but growing anatomical evidence …
health. Age-related cochlear cell death does occur, but growing anatomical evidence …
Two types of afferent terminals innervate cochlear inner hair cells in C57BL/6J mice
HW Francis, A Rivas, M Lehar, DK Ryugo - Brain research, 2004 - Elsevier
Afferent synapses on inner hair cells (IHC) transfer auditory information to the central
nervous system (CNS). Despite the importance of these synapses for normal hearing, their …
nervous system (CNS). Despite the importance of these synapses for normal hearing, their …
Selective hair cell ablation and noise exposure lead to different patterns of changes in the cochlea and the cochlear nucleus
T Kurioka, MY Lee, AN Heeringa, LA Beyer… - Neuroscience, 2016 - Elsevier
In experimental animal models of auditory hair cell (HC) loss, insults such as noise or
ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and …
ototoxic drugs often lead to secondary changes or degeneration in non-sensory cells and …
Functional alteration of ribbon synapses in inner hair cells by noise exposure causing hidden hearing loss
For decades, studies on noise-induced hearing loss have been focusing on the loss of
sensory hair cells and/or auditory afferent fibers following severe noise exposure. Recently …
sensory hair cells and/or auditory afferent fibers following severe noise exposure. Recently …
Evaluation of inner hair cell and nerve fiber loss as sufficient pathologies underlying auditory neuropathy
MM El-Badry, SL McFadden - Hearing research, 2009 - Elsevier
Auditory neuropathy is a hearing disorder characterized by normal function of outer hair
cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions …
cells, evidenced by intact cochlear microphonic (CM) potentials and otoacoustic emissions …