[HTML][HTML] The curious case of ZEB1

M Madany, T Thomas, LA Edwards - Discoveries, 2018 - ncbi.nlm.nih.gov
Abstract The Zinc Finger E-box binding homeobox (ZEB1/TCF8 or DeltaEF1) is at the
forefront of transcription factors involved in controlling epithelial-to-mesenchymal transitions …

Pleiotropic roles for ZEB1 in cancer

J Caramel, M Ligier, A Puisieux - Cancer research, 2018 - AACR
ZEB1 is a prime element of a network of transcription factors that controls epithelial-to-
mesenchymal transition (EMT), a reversible embryonic transdifferentiation program that …

Expression of the ZEB1 (δEF1) transcription factor in human: additional insights

EM Hurt, JN Saykally, BM Anose, KR Kalli… - Molecular and cellular …, 2008 - Springer
The zinc finger E-box binding transcription factor ZEB1 (δEF1/Nil-2-a/AREB6/zfhx1a/TCF8/
zfhep/BZP) is emerging as an important regulator of the epithelial to mesenchymal …

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with
the malignancy of various cancers. Signal transduction and activation of ZEB1 play …

[HTML][HTML] Regulation of ZEB1 function and molecular associations in tumor progression and metastasis

M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
Simple Summary Given the importance of the epithelial-to-mesenchymal transition in tumor
progression and the pivotal role of ZEB1 as a transcriptional repressor during this process …

[HTML][HTML] Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer

HT Wu, HT Zhong, GW Li, JX Shen, QQ Ye… - Journal of translational …, 2020 - Springer
Zinc finger E-box binding homeobox 1 (ZEB1, also termed TCF8 and δEF1) is a crucial
member of the zinc finger-homeodomain transcription factor family, originally identified as a …

Evolutionary functional analysis and molecular regulation of the ZEB transcription factors

A Gheldof, P Hulpiau, F Van Roy, B De Craene… - Cellular and Molecular …, 2012 - Springer
ZEB1 and ZEB2, which are members of the ZEB family of transcription factors, play a pivotal
role in the development of the vertebrate embryo. However, recent evidence shows that both …

Generation and characterization of mice for conditional inactivation of Zeb1

S Brabletz, M Lasierra Losada, O Schmalhofer… - genesis, 2017 - Wiley Online Library
The multizinc finger containing transcription factor ZEB1 plays crucial roles during various
aspects of mammalian development and tumorigenesis. Best studied in human tumors …

[HTML][HTML] Expanding roles of ZEB factors in tumorigenesis and tumor progression

E Sánchez-Tilló, L Siles, O De Barrios… - American journal of …, 2011 - ncbi.nlm.nih.gov
The ZEB family of transcription factors regulates key factors during embryonic development
and cell differentiation but their role in cancer biology has only more recently begun to be …

The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

K Aigner, B Dampier, L Descovich, M Mikula, A Sultan… - Oncogene, 2007 - nature.com
Epithelial to mesenchymal transition (EMT) is implicated in the progression of primary
tumours towards metastasis and is likely caused by a pathological activation of transcription …