Abstract Introduction T-helper 17 (Th17) cells produce IL-17A playing a critical role in
activating the pathogenic chain leading to joint tissue inflammation and destruction …

Background Interleukin (IL)-17A and Th17 cells are critically involved in T cell-mediated
synovial inflammation. Besides IL-17A, Th17 cells produce IL-22. Recently, Th22 cells were …

Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a
chronic autoimmune disease characterized by joint inflammation. Th17 development is …

Abstract IL-17A is a T cell-derived proinflammatory cytokine that contributes to the
pathogenesis of rheumatoid arthritis. Recently, six related molecules have been identified to …

Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental
arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis …

Purpose: Osteoarthritis (OA) is a chronic disabling disease characterized by destruction of
articular cartilage. Its pathogenesis is multifactorial and one of OA phenotype drivers is …

Background Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint
destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA …

Background Osteoarthritis (OA) is a progressive, chronic disease characterized by articular
cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported …

OBJECTIVE: Rheumatoid arthritis (RA) is one systemic auto-immune disorder featured as
chronic synovitis and can destruct joint cartilage. Fibroblast-like synoviocyte (FLS) secretes …

T cell IL-17 displays proinflammatory properties and is expressed in the synovium of patients
with rheumatoid arthritis. Its contribution to the arthritic process has not been identified. Here …