The properties inherent in poly (alkylcyanoacrylate)(PACA) nanoparticles, such as
biocompatibility and biodegradability of the polymer, a simple preparation process and …

Poly (alkylcyanoacrylate)(PACA) nanoparticles were first developed 25 years ago taking
advantage of the in vivo degradation potential of the polymer and of its good acceptance by …

Starting in the late 1970s, the pioneering work of Patrick Couvreur gave birth to the first
biodegradable nanoparticles composed of a biodegradable synthetic polymer. These …

The major problem in drug delivery to the brain is the presence of the blood–brain barrier
(BBB) which limits drug penetration even if in certain pathological situations the BBB is partly …

Abstract Poly (alkylcyanoacrylate)[PACA] nanoparticles have been studied since the early
1980s as possible colloidal drug delivery systems. Several excellent general reviews have …

Background Poly (alkyl cyanoacrylate)(PACA) nanoparticles have shown promise as drug
carriers both to solid tumors and across the blood–brain barrier. Efficient drug delivery …

This review considers the use of poly (alkylcyanoacrylates)(PACAs) as biomedical materials.
We first present the different aspects of the polymerization of alkylcyanoacrylate monomers …

Nanoparticles developed from poly (alkyl cyanoacrylate)(PACA) biodegradable polymers
have opened new and exciting perspectives in the field of drug delivery due to their nearly …

Some physicochemical behaviours were investigated of polyethyl-(PECA) and
polyisobutylcyanoacrylate (PICA), which, in recent years, have been proposed as …

First prepared in 1979, the colloidal nanoparticles based on biocompatible and bioerosive
poly (alkyl cyanoacrylate) materials are still under investigation and hold promise for the …