Importance Since the discovery ofBRCA1andBRCA2, multiple high-and moderate-
penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian …

Importance Germline pathogenic variants inBRCA1andBRCA2predispose to an increased
lifetime risk of breast cancer. However, the relevance of germline variants in other genes …

Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

Objective Genetic predisposition to ovarian cancer is well documented. With the advent of
next generation sequencing, hereditary panel testing provides an efficient method for …

Risk assessment coupled with genetic counseling and testing for the cancer predisposition
genes BRCA1 and BRCA2 (BRCA1/2) has become an integral element of comprehensive …

Purpose Many women with an elevated risk of hereditary breast and ovarian cancer have
previously tested negative for pathogenic mutations in BRCA1 and BRCA2. Among them, a …

Importance The clinical importance of genetic testing ofBRCA1andBRCA2in breast, ovarian,
prostate, and pancreatic cancers is widely recognized. However, there is insufficient …

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic
variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of …

Objective Germline mutations occurring in the highly penetrant genes BRCA1 and BRCA2
are responsible for only certain cases of familial breast cancer (BC) and ovarian cancer …

NGS‐based multiple gene panel resequencing in combination with a high resolution CGH‐
array was used to identify genetic risk factors for hereditary breast and/or ovarian cancer in …