Glycerol metabolism impacts biofilm phenotypes and virulence in Pseudomonas aeruginosa via the Entner-Doudoroff pathway

S Pan, SAM Underhill, CW Hamm, MA Stover… - Msphere, 2024 - Am Soc Microbiol
Pseudomonas aeruginosa is a ubiquitous bacterium and a notorious opportunistic pathogen
that forms biofilm structures in response to many environmental cues. Biofilm formation …

Glycerol metabolism promotes biofilm formation by Pseudomonas aeruginosa

J Scoffield, L Silo-Suh - Canadian journal of microbiology, 2016 - cdnsciencepub.com
Pseudomonas aeruginosa causes persistent infections in the airways of cystic fibrosis (CF)
patients. Airway sputum contains various host-derived nutrients that can be utilized by P …

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

Increased Osmolarity in Biofilm Triggers RcsB-Dependent Lipid A Palmitoylation in Escherichia coli

M Szczesny, C Beloin, JM Ghigo - MBio, 2018 - Am Soc Microbiol
Biofilms are often described as protective shelters that preserve bacteria from hostile
surroundings. However, biofilm bacteria are also exposed to various stresses and need to …

Biofilms Formed by Gram-Negative Bacteria Undergo Increased Lipid A Palmitoylation, Enhancing In Vivo Survival

S Chalabaev, A Chauhan, A Novikov, P Iyer… - MBio, 2014 - Am Soc Microbiol
Bacterial biofilm communities are associated with profound physiological changes that lead
to novel properties compared to the properties of individual (planktonic) bacteria. The study …

[HTML][HTML] Reverse diauxie phenotype in Pseudomonas aeruginosa biofilm revealed by exometabolomics and label-free proteomics

YP Yung, SL McGill, H Chen, H Park… - NPJ biofilms and …, 2019 - nature.com
Microorganisms enhance fitness by prioritizing catabolism of available carbon sources using
a process known as carbon catabolite repression (CCR). Planktonically grown …

Rhamnolipids mediate detachment of Pseudomonas aeruginosa from biofilms

BR Boles, M Thoendel, PK Singh - Molecular microbiology, 2005 - Wiley Online Library
The process of detachment, through which bacteria use active mechanisms to leave biofilms
and return to the planktonic (free‐living) state, is perhaps the least understood aspect of the …

[PDF][PDF] Pseudomonas aeruginosa and it's One of the Virulence Factors: Rhamnolipid

S Bukavaz - Infect Dis - academia.edu
Oppurtunistic pathogen Pseudomonas aeruginosa is known as most adaptive bacteria to
diversity of ecological niches thanks to their multifactorial regulating system and non …

Glucose-6-Phosphate Acts as an Extracellular Signal of SagS To Modulate Pseudomonas aeruginosa c-di-GMP Levels, Attachment, and Biofilm Formation

S Park, J Dingemans, M Gowett, K Sauer - Msphere, 2021 - Am Soc Microbiol
In Pseudomonas aeruginosa, the orphan two-component sensor SagS contributes both to
transition to biofilm formation and to biofilm cells gaining their heightened tolerance to …

[HTML][HTML] Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence

E Razvi, GB Whitfield, C Reichhardt… - npj Biofilms and …, 2023 - nature.com
Pel exopolysaccharide biosynthetic loci are phylogenetically widespread biofilm matrix
determinants in bacteria. In Pseudomonas aeruginosa, Pel is crucial for cell-to-cell …