[HTML][HTML] The Versatile Mutational Resistome of Pseudomonas aeruginosa

C López-Causapé, G Cabot… - Frontiers in …, 2018 - frontiersin.org
One of the most striking features of Pseudomonas aeruginosa is its outstanding capacity for
developing antimicrobial resistance to nearly all available antipseudomonal agents through …

Deciphering the resistome of the widespread Pseudomonas aeruginosa sequence type 175 international high-risk clone through whole-genome sequencing

G Cabot, C López-Causapé… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Whole-genome sequencing (WGS) was used for the characterization of the frequently
extensively drug resistant (XDR) Pseudomonas aeruginosa sequence type 175 (ST175) …

Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa

A Khaledi, M Schniederjans, S Pohl… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Emerging resistance to antimicrobials and the lack of new antibiotic drug candidates
underscore the need for optimization of current diagnostics and therapies to diminish the …

The resistome of Pseudomonas aeruginosa in relationship to phenotypic susceptibility

VN Kos, M Déraspe, RE McLaughlin… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Many clinical isolates of Pseudomonas aeruginosa cause infections that are difficult to
eradicate due to their resistance to a wide variety of antibiotics. Key genetic determinants of …

Genomewide Identification of Genetic Determinants of Antimicrobial Drug Resistance in Pseudomonas aeruginosa

A Dötsch, T Becker, C Pommerenke… - Antimicrobial agents …, 2009 - Am Soc Microbiol
The emergence of antimicrobial drug resistance is of enormous public concern due to the
increased risk of delayed treatment of infections, the increased length of hospital stays, the …

[HTML][HTML] Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa

W Hwang, SS Yoon - Scientific reports, 2019 - nature.com
Pseudomonas aeruginosa displays intrinsic resistance to many antibiotics and known to
acquire actively genetic mutations for further resistance. In this study, we attempted to …

Evolution of Pseudomonas aeruginosa antimicrobial resistance and fitness under low and high mutation rates

G Cabot, L Zamorano, B Moyà, C Juan… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Pseudomonas aeruginosa, a major cause of nosocomial and chronic infections, is
considered a paradigm of antimicrobial resistance development. However, the evolutionary …

Hypermutator Pseudomonas aeruginosa exploits multiple genetic pathways to develop multidrug resistance during long-term infections in the airways of cystic fibrosis …

CA Colque, AG Albarracín Orio, S Feliziani… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

[HTML][HTML] The neglected intrinsic resistome of bacterial pathogens

A Fajardo, N Martínez-Martín, M Mercadillo, JC Galán… - PloS one, 2008 - journals.plos.org
Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely
believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence …