Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined …
RB Conolly, JS Kimbell, D Janszen… - Toxicological …, 2004 - academic.oup.com
Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma
(SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are …
(SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are …
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat
RB Conolly, JS Kimbell, D Janszen… - Toxicological …, 2003 - academic.oup.com
Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma
(SCC) in F344 rats. The human health implications of this effect are of significant interest …
(SCC) in F344 rats. The human health implications of this effect are of significant interest …
Quantitative cancer risk estimation for formaldehyde
TB Starr - Risk Analysis, 1990 - Wiley Online Library
Of primary concern are irreversible effects, such as cancer induction, that formaldehyde
exposure could have on human health. Dose‐response data from human exposure …
exposure could have on human health. Dose‐response data from human exposure …
Benchmark dose risk assessment for formaldehyde using airflow modeling and a single‐compartment, DNA‐protein cross‐link dosimetry model to estimate human …
PM Schlosser, PD Lilly, RB Conolly… - Risk Analysis: An …, 2003 - Wiley Online Library
Formaldehyde induced squamous‐cell carcinomas in the nasal passages of F344 rats in
two inhalation bioassays at exposure levels of 6 ppm and above. Increases in rates of cell …
two inhalation bioassays at exposure levels of 6 ppm and above. Increases in rates of cell …
An approach to mechanism-based cancer risk assessment for formaldehyde.
RB Conolly, ME Andersen - Environmental health perspectives, 1993 - ehp.niehs.nih.gov
The established carcinogenicity of formaldehyde in the rat and suggestive epidemiological
evidence that formaldehyde may be a human carcinogen have led to its regulation by US …
evidence that formaldehyde may be a human carcinogen have led to its regulation by US …
Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
RB Conolly, PD Lilly, JS Kimbell - Environmental health perspectives, 2000 - JSTOR
Formaldehyde inhalation causes formation of DNA-protein cross-links (DPX) in the nasal
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
Inhaled formaldehyde: exposure estimation, hazard characterization, and exposure-response analysis
RG Liteplo, ME Meek - Journal of Toxicology and Environmental …, 2003 - Taylor & Francis
Formaldehyde has been assessed as a Priority Substance under the Canadian
Environmental Protection Act. Probabilistic estimates of exposure of the general population …
Environmental Protection Act. Probabilistic estimates of exposure of the general population …
Dosimetry modeling of inhaled formaldehyde: the human respiratory tract
JH Overton, JS Kimbell, FJ Miller - Toxicological Sciences, 2001 - academic.oup.com
Formaldehyde (HCHO), which has been shown to be a nasal carcinogen in rats and mice, is
used widely and extensively in various manufacturing processes. Studies in rhesus …
used widely and extensively in various manufacturing processes. Studies in rhesus …
Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages
JS Kimbell, RP Subramaniam, EA Gross… - Toxicological …, 2001 - academic.oup.com
Formaldehyde-induced nasal squamous cell carcinomas in rats and squamous metaplasia
in rats and rhesus monkeys occur in specific regions of the nose with species-specific …
in rats and rhesus monkeys occur in specific regions of the nose with species-specific …
Effects of endogenous formaldehyde in nasal tissues on inhaled formaldehyde dosimetry predictions in the rat, monkey, and human nasal passages
JD Schroeter, J Campbell, JS Kimbell… - Toxicological …, 2014 - academic.oup.com
Formaldehyde is a nasal carcinogen in rodents at high doses and is an endogenous
compound that is present in all living cells. Due to its high solubility and reactivity …
compound that is present in all living cells. Due to its high solubility and reactivity …