Oxytocin treatment prevents the cardiomyopathy observed in obese diabetic male db/db mice

E Plante, A Menaouar, BA Danalache, D Yip… - …, 2015 - academic.oup.com
Oxytocin (OT) is involved in the regulation of energy metabolism and in the activation of
cardioprotective mechanisms. We evaluated whether chronic treatment with OT could …

[HTML][HTML] Oxytocin and cardioprotection in diabetes and obesity

M Jankowski, TL Broderick, J Gutkowska - BMC Endocrine Disorders, 2016 - Springer
Oxytocin (OT) emerges as a drug for the treatment of diabetes and obesity. The entire OT
system is synthesized in the rat and human heart. The direct myocardial infusion with OT into …

Downregulation of oxytocin and natriuretic peptides in diabetes: possible implications in cardiomyopathy

J Gutkowska, TL Broderick, D Bogdan… - The Journal of …, 2009 - Wiley Online Library
Regular physical activity is beneficial in preventing the risk of cardiovascular complications
of diabetes. Recent studies showed a cardioprotective role of oxytocin (OT) to induce …

Oxytocin revisited: its role in cardiovascular regulation

J Gutkowska, M Jankowski - Journal of neuroendocrinology, 2012 - Wiley Online Library
Traditionally associated with female reproduction, oxytocin (OT) was revisited recently and
was revealed to have several new roles in the cardiovascular system. Functional OT …

Divergent effects of oxytocin treatment of obese diabetic mice on adiposity and diabetes

J Altirriba, AL Poher, A Caillon, D Arsenijevic… - …, 2014 - academic.oup.com
Oxytocin has been suggested as a novel therapeutic against obesity, because it induces
weight loss and improves glucose tolerance in diet-induced obese rodents. A recent clinical …

Oxytocin improves β-cell responsivity and glucose tolerance in healthy men

J Klement, V Ott, K Rapp, S Brede, F Piccinini… - Diabetes, 2017 - Am Diabetes Assoc
In addition to its pivotal role in psychosocial behavior, the hypothalamic neuropeptide
oxytocin contributes to metabolic control by suppressing eating behavior. Its involvement in …

Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice

LC Michelini, MC Marcelo, J Amico… - American Journal of …, 2003 - journals.physiology.org
Oxytocin (OT) has been implicated in the cardiovascular responses to exercise, stress, and
baroreflex adjustments. Studies were conducted to determine the effect of genetic …

Cardiac oxytocin receptor blockade stimulates adverse cardiac remodeling in ovariectomized spontaneously hypertensive rats

M Jankowski, D Wang, B Danalache… - American Journal …, 2010 - journals.physiology.org
An increasing amount of evidence demonstrates the beneficial role of oxytocin (OT) in the
cardiovascular system. Similar actions are attributed to genistein, an isoflavonic …

Oxytocin in metabolic homeostasis: implications for obesity and diabetes management

C Ding, MKS Leow, F Magkos - Obesity Reviews, 2019 - Wiley Online Library
Oxytocin was once understood solely as a neuropeptide with a central role in social
bonding, reproduction, parturition, lactation and appetite regulation. Recent evidence …

[HTML][HTML] Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats

N Deblon, C Veyrat-Durebex, L Bourgoin, A Caillon… - PloS one, 2011 - journals.plos.org
Apart from its role during labor and lactation, oxytocin is involved in several other functions.
Interestingly, oxytocin-and oxytocin receptor-deficient mice develop late-onset obesity with …