Using cDNA cloning strategies commonly employed for G protein-coupled receptors
(GPCR), GPCR-30 (GPR30), was isolated from mammalian cells before knowledge of its …

GPR30, now named GPER1 (G protein-coupled estrogen receptor1) or GPER here, was first
identified as an orphan 7-transmembrane G protein-coupled receptor by multiple …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

Estrogens are sex hormones that are central to health and disease in both genders. These
hormones have long been recognized to act in complex ways, both through relatively slow …

Estrogens play an important role in the regulation of normal physiology, aging and many
disease states. Although the nuclear estrogen receptors have classically been described to …

Rapid signaling of estrogen involves membrane estrogen receptors (ERs), including
membrane subpopulations of ERα and ERβ. In the mid-1990s, several laboratories …

Abstract Estrogens, predominantly 17β-estradiol, exert diverse effects throughout the body in
both normal and pathophysiology, during development and in reproductive, metabolic …

Estrogen can elicit pleiotropic cellular responses via a diversity of estrogen receptors (ERs)—
mediated genomic and rapid non-genomic mechanisms. Unlike the genomic responses …

GPER possesses structural and functional characteristics shared by members of the G-
protein-coupled receptor (GPCR) superfamily, the largest class of plasma membrane …