Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism
and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of …

Purified human liver carboxylesterase (hCE-1) catalyzes the hydrolysis of cocaine to form
benzoylecgonine, the deacetylation of heroin to form 6-acetylmorphine, and the ethanol …

A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of
cocaine and the acetyl groups of 4-methylumbelliferyl acetate, heroin, and 6 …

Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE,
HU3) are a serine esterase involved in both drug metabolism and activation. Although both …

Human carboxylesterase 1 (hCE1) exhibits broad substrate specificity and is involved in
xenobiotic processing and endobiotic metabolism. We present and analyze crystal …

Human carboxylesterase 1 (hCE1) is a drug and endobiotic-processing serine hydrolase
that exhibits relatively broad substrate specificity. It has been implicated in a variety of …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

Carboxylesterase 1 (CES1) is the major hydrolase in human liver. The enzyme is involved in
the metabolism of several important therapeutic agents, drugs of abuse, and endogenous …

We present the first crystal structures of a human protein bound to analogs of cocaine and
heroin. Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes …

Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a
variety of drug esters, amides, carbamates and similar structures. There are five …