Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes
generated in the C3 and C5 convertases of the complement system, causing its …

Autoantibodies termed C3-nephritic factor (C3NeF), which stabilize convertases of the
alternative complement pathway, often stimulate autoinflammatory diseases. However …

C3 deficiency is a rare disorder that leads to recurrent pyogenic infections. Here we describe
a previously healthy 18 y/o Caucasian male with severe meningococcal disease. Total …

The alternative pathway of complement is implicated in the pathogenesis of several renal
diseases, such as atypical hemolytic uremic syndrome, dense deposit disease and other …

C3 Glomerulopathies, which include Dense Deposit Disease and C3 Glomerulonephritis,
are associated with genetic and acquired dysregulation of the C3 convertase alternative …

C3 nephritic factors are autoantibodies that prolong the half-life or prevent regulation of the
alternative pathway C3 convertase, resulting in uncontrolled complement activation. They …

Membranoproliferative glomerulonephritis (MPGN) is a rare chronic kidney disease
associated with complement activation. Recent immunofluorescence-based classification …

Background C3 glomerulopathy (C3G) defines a group of rare complement-mediated kidney
diseases with a shared underlying pathophysiology: dysregulation of complement in the …

Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3
glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the …

C3 glomerulopathy describes a spectrum of disorders with glomerular pathology associated
with C3 cleavage product deposition and with defective complement action and regulation …