Highlights•Food rewards elicit affective responses that emerge from multiple
components.•These components are known to rely on distinct neurobiological …

In the development of addiction, drug seeking becomes habitual and controlled by drug-
associated cues, and the neural locus of control over behaviour shifts from the ventral to the …

BACKGROUND: Cue reactivity, the ability of cues associated with addictive substances to
induce seeking and withdrawal, is a major contributor to addiction. Although human imaging …

Although midbrain dopamine (DA) circuits are central to motivated behaviors, our
knowledge of how experience modifies these circuits to facilitate subsequent behavioral …

Findings have shown that anterior insular cortex (aIC) lesions disrupt the maintenance of
drug addiction, while imaging studies suggest that connections between amygdala and aIC …

Cocaine-associated memories are critical drivers of relapse in cocaine-dependent
individuals that can be evoked by exposure to cocaine or stress. Whether these …

Background The human brain responds to recognizable signals for sex and for rewarding
drugs of abuse by activation of limbic reward circuitry. Does the brain respond in similar way …

Craving reflects the subjective urge to use drugs and can be triggered by both positive and
negative emotional states. No studies have systematically investigated the relative roles of …

Rats trained to perform a version of the rat gambling task (rGT) in which salient audiovisual
cues accompany reward delivery, similar to commercial gambling products, show greater …

The anterior insular cortex (AIC) has been implicated in addictive behaviour, including the
loss of control over drug intake, craving and the propensity to relapse. Evidence suggests …