Relative contributions of endogenous and exogenous formaldehyde to formation of deoxyguanosine monoadducts and DNA-protein crosslink adducts of DNA in rat …
RB Conolly, JL Campbell, HJ Clewell… - Toxicological …, 2023 - academic.oup.com
Understanding the dose-response for formaldehyde-induced nasal cancer in rats is
complicated by (1) the uneven distribution of inhaled formaldehyde across the interior …
complicated by (1) the uneven distribution of inhaled formaldehyde across the interior …
A kinetic analysis of DNA-deoxy guanine adducts in the nasal epithelium produced by inhaled formaldehyde in rats—assessing contributions to adduct production …
JL Campbell Jr, PR Gentry, HJ Clewell III… - Toxicological …, 2020 - academic.oup.com
Although formaldehyde is a normal constituent of tissues, lifetime inhalation exposures at 6
h/day, 5 days/week at concentrations≥ 6 ppm caused a nonlinear increase in nasal tumors …
h/day, 5 days/week at concentrations≥ 6 ppm caused a nonlinear increase in nasal tumors …
Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
RB Conolly, PD Lilly, JS Kimbell - Environmental health perspectives, 2000 - JSTOR
Formaldehyde inhalation causes formation of DNA-protein cross-links (DPX) in the nasal
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
mucosa of Fischer 344 (F344) rats and rhesus monkeys. DPX are considered to be part of …
A distributed-parameter model for formaldehyde uptake and disposition in the rat nasal lining
AV Georgieva, JS Kimbell, PM Schlosser - Inhalation toxicology, 2003 - Taylor & Francis
DNA–protein cross-links (DPX) serve as a dosimeter for inhaled formaldehyde and are
associated with tumor induction in rat nasal passages after chronic exposure to 6 ppm and …
associated with tumor induction in rat nasal passages after chronic exposure to 6 ppm and …
Nasal dosimetry of formaldehyde: Modeling site specificity and the effects of preexposure
HA Heck, M Casanova - Inhalation Toxicology, 1994 - Taylor & Francis
The formation of DNA-protein cross-links (DPX) in the nose of F344 rats exposed to
formaldehyde (HCHO) is site specific and depends on the prior exposure history of the …
formaldehyde (HCHO) is site specific and depends on the prior exposure history of the …
Comparison of inhaled formaldehyde dosimetry predictions with DNA–protein cross-link measurements in the rat nasal passages
EAC Hubal, PM Schlosser, RB Conolly… - Toxicology and applied …, 1997 - Elsevier
Kimbell and coworkers (Toxicol. Appl. Pharmacol. 121,253–263, 1993) developed a
computational fluid dynamics (CFD) model of a F344 rat nasal passage to quantify local wall …
computational fluid dynamics (CFD) model of a F344 rat nasal passage to quantify local wall …
Updating the biologically based dose-response model for the nasal carcinogenicity of inhaled formaldehyde in the F344 rat
RB Conolly, J Schroeter, JS Kimbell… - Toxicological …, 2023 - academic.oup.com
Chronic inhalation of formaldehyde by F344 rats causes nasal squamous cell carcinoma
(SCC). This outcome is well-characterized: including dose-response and time course data …
(SCC). This outcome is well-characterized: including dose-response and time course data …
Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined …
RB Conolly, JS Kimbell, D Janszen… - Toxicological …, 2004 - academic.oup.com
Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma
(SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are …
(SCC) in F344 rats. The quantitative implications of the rat tumors for human cancer risk are …
Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation
CC Conaway, J Whysner, LK Verna… - Pharmacology & …, 1996 - Elsevier
Exposures of rodents to airborne formaldehyde (FA) produce dose-related toxicity,
enhanced cell proliferation and squamous cell carcinomas in the nasal passages. The …
enhanced cell proliferation and squamous cell carcinomas in the nasal passages. The …
Pharmacodynamics of formaldehyde: applications of a model for the arrest of DNA replication by DNA–protein cross-links
HA Heck, M Casanova - Toxicology and applied pharmacology, 1999 - Elsevier
A variety of evidence suggests that formaldehyde (HCHO)-induced DNA–protein cross-links
(DPX) are genotoxic as a result of their ability to arrest DNA replication. Although DPX can …
(DPX) are genotoxic as a result of their ability to arrest DNA replication. Although DPX can …