[引用][C] A biologically-based risk assessment strategy for inhaled formaldehyde
RB Conolly, KT Morgan, ME Anderson, TM Monticello… - Comments on Toxicology, 1992
Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages
JS Kimbell, RP Subramaniam, EA Gross… - Toxicological …, 2001 - academic.oup.com
Formaldehyde-induced nasal squamous cell carcinomas in rats and squamous metaplasia
in rats and rhesus monkeys occur in specific regions of the nose with species-specific …
in rats and rhesus monkeys occur in specific regions of the nose with species-specific …
Further considerations for the implausibility of leukemia induction by formaldehyde
K Lu, BC Moeller, JA Swenberg - Toxicological Sciences, 2011 - academic.oup.com
We fully agree with Thompson and Grafstrom for the ''need to further examine the
epidemiological evidence for the association between formaldehyde exposure and …
epidemiological evidence for the association between formaldehyde exposure and …
Differentiation between metabolic incorporation and covalent binding in the labeling of macromolecules in the rat nasal mucosa and bone marrow by inhaled [14C] …
M Casanova-Schmitz, TB Starr, HA Heck - Toxicology and applied …, 1984 - Elsevier
The mechanisms of labeling of macromolecules (DNA, RNA, and protein) in the respiratory
and olfactory mucosa, and in the bone marrow (femur) of male Fischer-344 rats exposed to …
and olfactory mucosa, and in the bone marrow (femur) of male Fischer-344 rats exposed to …
DNA–Protein Cross-Links (DPX) and Cell Proliferation in B6C3F1Mice but Not Syrian Golden Hamsters Exposed to Dichloromethane: Pharmacokinetics and Risk …
M Casanova, RB Conolly, HA Heck - Fundamental and Applied Toxicology, 1996 - Elsevier
Dichloromethane (DCM)(methylene chloride; CH2Cl2) is metabolized via a glutathioneS-
transferase-mediated pathway to formaldehyde (HCHO), a mutagenic compound that could …
transferase-mediated pathway to formaldehyde (HCHO), a mutagenic compound that could …
[HTML][HTML] The bottom-up approach to bounding potential low-dose cancer risks from formaldehyde: An update
TB Starr, JA Swenberg - Regulatory Toxicology and Pharmacology, 2016 - Elsevier
In 2013, we proposed a novel bottom-up approach to bounding low-dose cancer risks that
may result from small exogenous exposures to chemicals that are always present in the …
may result from small exogenous exposures to chemicals that are always present in the …
A parallelogram approach for safety evaluation of ingested acetaldehyde
JB Morris, DE Robinson, TA Vollmuth, RP Brown… - Regulatory toxicology …, 1996 - Elsevier
Route-specific carcinogenicity data are often lacking for compounds of regulatory
importance. Acetaldehyde (AA), for example, a natural constituent in foods, is a rodent …
importance. Acetaldehyde (AA), for example, a natural constituent in foods, is a rodent …
Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to …
SD Hester, WT Barry, F Zou… - Toxicologic pathology, 2005 - journals.sagepub.com
Formaldehyde is cytotoxic and carcinogenic to the rat nasal respiratory epithelium inducing
tumors after 12 months. Glutaraldehyde is also cytotoxic but is not carcinogenic to nasal …
tumors after 12 months. Glutaraldehyde is also cytotoxic but is not carcinogenic to nasal …
DNA damage in the nasal passageway: a literature review
BH Mathison, AE Harman, MS Bogdanffy - Mutation Research/Fundamental …, 1997 - Elsevier
The purpose of this review is to provide a compilation of work examining DNA damage in the
nasal cavity. There are numerous methods to identify and quantify damage to DNA and the …
nasal cavity. There are numerous methods to identify and quantify damage to DNA and the …
Formaldehyde: integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound
ME Andersen, HJ Clewell III, E Bermudez… - Toxicological …, 2010 - academic.oup.com
Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this
study, concentration and exposure duration transitions in FA mode of action (MOA) were …
study, concentration and exposure duration transitions in FA mode of action (MOA) were …