The present perspective article proposes that cachexia, muscle wasting in cancer, is
mediated by dysregulated phosphate metabolism and phosphate toxicity that can damage …

Simple Summary In spontaneous tumor regression, tumors shrink and disappear without
conventional treatments. This phenomenon challenges the view that cancer is an …

Background Altered cell metabolism is regarded as a hallmark of cancer with numerous
studies highlighting glucose and glutamine as critical nutrients for tumor proliferation …

In this article, we briefly summarized evidence that cellular phosphate burden from
phosphate toxicity is a pathophysiological determinant of cancer cell growth. Tumor cells …

Phosphorus, often in the form of inorganic phosphate (Pi), is critical to cellular function on
many levels; it is required as an integral component of kinase signaling, in the formation and …

Inorganic phosphate (Pi) is required by all living organisms for the development of organs
such as bone, muscle, brain, and lungs, regulating the expression of several critical genes …

Identifying factors that accelerate the aging process can provide important therapeutic
targets for slowing down this process. Misregulation of phosphate homeostasis has been …

Inorganic phosphate (Pi) is an essential nutrient to living organisms. It is required as a
component of the energy metabolism, kinase/phosphatase signaling and in the formation …

Background: Cancer therapeutics have a low success rate in clinical trials. An
interdisciplinary approach is needed to translate basic, clinical, and remote fields of …

Cellular senescence is one type of permeant arrest of cell growth and one of increasingly
recognized contributor to aging and age-associated disease. High phosphate and low …