Functional Analysis of All Nonribosomal Peptide Synthetases in Cochliobolus heterostrophus Reveals a Factor, NPS6, Involved in Virulence and Resistance to …

BN Lee, S Kroken, DYT Chou, B Robbertse… - Eukaryotic …, 2005 - Am Soc Microbiol
Nonribosomal peptides, made by nonribosomal peptide synthetases, have diverse
biological activities, including roles as fungal virulence effectors. Inspection of the genome of …

Creating and screening Cochliobolus heterostrophus non-ribosomal peptide synthetase mutants

BG Turgeon, S Oide, K Bushley - Mycological research, 2008 - Elsevier
An exhaustive characterization of the set of non-ribosomal peptide synthetase (NRPS)
genes of the corn pathogen, Cochliobolus heterostrophus, and the small molecule peptides …

Interkingdom gene transfer of a hybrid NPS/PKS from bacteria to filamentous ascomycota

DP Lawrence, S Kroken, BM Pryor, AE Arnold - PloS one, 2011 - journals.plos.org
Nonribosomal peptides (NRPs) and polyketides (PKs) are ecologically important secondary
metabolites produced by bacteria and fungi using multidomain enzymes called …

Endogenous cross-talk of fungal metabolites

KJ Sheridan, SK Dolan, S Doyle - Frontiers in Microbiology, 2015 - frontiersin.org
Non-ribosomal peptide (NRP) synthesis in fungi requires a ready supply of proteogenic and
non-proteogenic amino acids which are subsequently incorporated into the nascent NRP via …

A genome-wide analysis of nonribosomal peptide synthetase gene clusters and their peptides in a Planktothrix rubescens strain

TB Rounge, T Rohrlack, AJ Nederbragt, T Kristensen… - BMC genomics, 2009 - Springer
Background Cyanobacteria often produce several different oligopeptides, with unknown
biological functions, by nonribosomal peptide synthetases (NRPS). Although some …

Natural roles of nonribosomal peptide metabolites in fungi

S Oide, BG Turgeon - Mycoscience, 2020 - jstage.jst.go.jp
abstract Over 90 years have passed since Alexander Fleming's discovery of penicillin, the
first recognized, naturally occurring antibiotic. Penicillin is a representative of a group of …

Sfp‐type 4′‐phosphopantetheinyl transferase is required for lysine synthesis, tolerance to oxidative stress and virulence in the plant pathogenic fungus Cochliobolus …

Y Leng, S Zhong - Molecular Plant Pathology, 2012 - Wiley Online Library
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are the major
enzymes involved in the biosynthesis of secondary metabolites, which have diverse …

Phylogenetic study of polyketide synthases and nonribosomal peptide synthetases involved in the biosynthesis of mycotoxins

A Gallo, M Ferrara, G Perrone - Toxins, 2013 - mdpi.com
Polyketide synthase (PKSs) and nonribosomal peptide synthetase (NRPSs) are large
multimodular enzymes involved in biosynthesis of polyketide and peptide toxins produced …

Deletion of the nonribosomal peptide synthetase gene nps1 in the fungus Clonostachys rosea attenuates antagonism and biocontrol of plant pathogenic Fusarium …

M Iqbal, M Dubey, A Broberg, M Viketoft… - …, 2019 - Am Phytopath Society
Secondary metabolites produced by biological control agents may influence the outcome of
their interactions with plant pathogenic microorganisms and plants. In the present study, we …

Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships

KE Bushley, BG Turgeon - BMC evolutionary biology, 2010 - Springer
Abstract Background Nonribosomal peptide synthetases (NRPSs) are multimodular
enzymes, found in fungi and bacteria, which biosynthesize peptides without the aid of …