MicroRNAs and their delivery in diabetic fibrosis

A Wonnacott, L Denby, RJM Coward, DJ Fraser… - Advanced drug delivery …, 2022 - Elsevier
The global prevalence of diabetes mellitus was estimated to be 463 million people in 2019
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …

MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications

R Regazzi - Expert opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Diabetes mellitus is a very common metabolic disorder affecting more than 400
million people worldwide. Currently available treatments permit to manage the disease but …

The role of micrornas in diabetic complications—special emphasis on wound healing

J Moura, E Børsheim, E Carvalho - Genes, 2014 - mdpi.com
Overweight and obesity are major problems in today's society, driving the prevalence of
diabetes and its related complications. It is important to understand the molecular …

MicroRNAs in diabetes and diabetes-associated complications

J Lorenzen, R Kumarswamy, S Dangwal, T Thum - RNA biology, 2012 - Taylor & Francis
Diabetes mellitus due to its high prevalence and associated complications is a major
socioeconomic health problem. Diabetes is characterized by multiple macro-and …

Emerging roles for microRNAs in diabetic microvascular disease: novel targets for therapy

Y Zhang, X Sun, B Icli, MW Feinberg - Endocrinology Reviews, 2017 - academic.oup.com
Chronic, low-grade systemic inflammation and impaired microvascular function are critical
hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major …

MicroRNAs: the underlying mediators of pathogenetic processes in vascular complications of diabetes

MA Ruiz, S Chakrabarti - Canadian journal of diabetes, 2013 - Elsevier
Diabetes mellitus causes chronic complications primarily affecting the vasculature of various
organs, risking patients for renal failure, vision loss and heart failure. A newly discovered …

Towards microRNA-based therapeutics for diabetic nephropathy

ML Alvarez, JK DiStefano - Diabetologia, 2013 - Springer
There is no cure for diabetic nephropathy and the molecular mechanisms underlying
disease aetiology remain poorly understood. While current paradigms for clinical …

microRNA in the development of diabetic complications

AD McClelland, P Kantharidis - Clinical science, 2014 - portlandpress.com
Today's world population is currently faced with a new type of non-transmissible pandemic:
obesity. This lifestyle-related condition is driving the emergence of the diabetes pandemic …

Role and therapeutic potential of microRNAs in diabetes

IGM Kolfschoten, E Roggli, V Nesca… - Diabetes, Obesity and …, 2009 - Wiley Online Library
The discovery in mammalian cells of hundreds of small RNA molecules, called microRNAs,
with the potential to modulate the expression of the majority of the protein‐coding genes has …

MicroRNAs and diabetic complications

R Natarajan, S Putta, M Kato - Journal of cardiovascular translational …, 2012 - Springer
Abstract Both Type 1 and Type 2 diabetes can lead to debilitating microvascular
complications such as retinopathy, nephropathy and neuropathy, as well as macrovascular …