The last two decades have boosted research on sphingolipids as bioactive and signaling
molecules. Certain sphingolipid species, such as ceramide, sphingosine, and sphingosine 1 …

Background Men have a higher risk for cardiovascular disease (CVD) early in life, while
women have a higher risk later in life. The sex-related differences in CVD risk, especially by …

Background Dysfunctional lipid metabolism is a hallmark of obesity and insulin resistance
and a risk factor for various cardiovascular and metabolic complications. In addition to the …

Sphinganine and sphingosine, the two sphingoid base backbones of sphingolipids, are
highly bioactive compounds that are of increasing interest to nutritionists because they occur …

The purpose of this study was to determine low-grade inflammation associated with obesity
that is mediated partially by TNF-α, an adipocytokine which stimulates sphingomyelinase …

Premature infants are born with developing lungs burdened by surfactant deficiency and a
dearth of antioxidant defense systems. Survival rate of such infants has significantly …

Sphingolipids (SLs) have a biomodulatory role in physiological as well as pathological
cardiovascular conditions. This study aims to assess the variation of SL mediators and …

Background In recent years, there has been increasing evidence that several lipid
metabolism abnormalities play an important role in the pathogenesis of neurodegenerative …

We used a HPLC-MS/MS methodology for determination of a basic metabolomic profile (18:
1, 18: 0 sphingoid backbone, C 14-C 26 N-acyl part) of" normal" sphingolipid levels in …

Sphingolipid concentrations have been associated with risk of type 2 diabetes and
cardiovascular diseases. Because sphingolipids can be synthesized de novo from saturated …