Objectives Concentrations of plasminogen activator inhibitor-1 (PAI-1) are increased in
obese individuals. One source of PAI-1 is adipocytes. Hypoxia develops within adipose …

Obesity is a global health issue for which no major effective treatments have been well
established. High-fat diet consumption is closely related to the development of obesity …

Aims/hypothesis Sphingolipid synthesis is typically initiated by the conjugation of l-serine
and palmitoyl-CoA, a reaction catalysed by serine palmitoyltransferase (SPT). SPT can also …

Ascent to high-altitude results in decreased inspired partial pressure of oxygen because of a
decrease in barometric pressure. Altitude acclimatization requires physiological and …

Sphingolipids (SPs) comprise a highly diverse class of lipids that serve biological roles both
as structural components of cell membranes and as mediators of cell signaling …

Abstract Both sphingosine 1-phosphate (S1P) and estrogen have been documented to play
endothelial protective roles. However, it remains unclear whether estrogen could regulate …

Abstract Background Sphingosine-1-Phosphate (S1P) is a bioactive lipid and an
intracellular as well as an extracellular signaling molecule. S1P ligand specifically binds to …

Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid that has pleiotropic
effects in a variety of cell types including ECs, SMCs, and macrophages, all of which are …

Sphingolipids, together with phospholipids and cholesterol are key components of
membrane lipid bilayers, contribute to specialized membrane domains called rafts and …

Abstract Development of rapid metabolomic methods poised for pathway discovery is
expected to facilitate the identification of therapeutic candidates in the metabolomic …