Clinical characterization and treatment patterns for the frequent exacerbator phenotype in chronic obstructive pulmonary disease with severe or very severe airflow …

F Blasi, L Neri, S Centanni, F Falcone… - COPD: Journal of …, 2017 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) patients experiencing several episodes of
acute clinical derangement suffer from increased morbidity, mortality, and accelerated …

Clinical and functional lung parameters associated with frequent exacerbator phenotype in subjects with severe COPD

A Capozzolo, P Carratù, S Dragonieri… - Respiratory …, 2017 - rc.rcjournal.com
BACKGROUND: COPD is currently recognized as a syndrome associated with a high
prevalence of comorbidities and various phenotypes. Exacerbations are very important …

Defining the “frequent exacerbator” phenotype in COPD: a hypothesis-free approach

O Le Rouzic, N Roche, AB Cortot, I Tillie-Leblond… - Chest, 2018 - Elsevier
Background The COPD “frequent exacerbator” phenotype is usually defined by at least two
treated exacerbations per year and is associated with a huge impact on patient health …

Frequent chronic obstructive pulmonary disease exacerbators: how much real, how much fictitious?

JJ Soler-Cataluña… - COPD: Journal of Chronic …, 2010 - Taylor & Francis
Exacerbations are important events in the natural history of chronic obstructive pulmonary
disease (COPD). The higher the number of COPD exacerbations, the worse are the clinical …

Predictors of hospitalized exacerbations and mortality in chronic obstructive pulmonary disease

M Santibanez, R Garrastazu, M Ruiz-Nunez… - PLoS …, 2016 - journals.plos.org
Background and Aim Exacerbations of chronic obstructive pulmonary disease (COPD) carry
significant consequences for patients and are responsible for considerable health-care costs …

Characterization associated with the frequent severe exacerbator phenotype in COPD patients

YK Wu, WL Su, MC Yang, SY Chen… - International journal of …, 2021 - Taylor & Francis
Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory
disease with exacerbations causing hospitalizations, morbidity, and mortality. COPD …

Factors Associated with the Non-Exacerbator Phenotype of Chronic Obstructive Pulmonary Disease

D Bouhuis, M Giezeman, M Hasselgren… - … Journal of Chronic …, 2023 - Taylor & Francis
Background Patients with chronic obstructive pulmonary disease (COPD) and no
exacerbations may need less maintenance treatment and follow-up. The aim was to identify …

[HTML][HTML] Chronic Obstructive Pulmonary Disease with Frequent Exacerbator Phenotype: What is Different in these Patients?

B Uslu, A Gülsen, BA Yigitbas - Tanaffos, 2022 - ncbi.nlm.nih.gov
Background: Acute exacerbation events, which can develop during the natural course of
chronic obstructive pulmonary disease (COPD) can lead to worsening quality of life …

Subtypes of Patients with Mild to Moderate Airflow Limitation as Predictors of Chronic Obstructive Pulmonary Disease Exacerbation

NE Kim, EH Kang, JY Jung, CY Lee, WY Lee… - Journal of Clinical …, 2023 - mdpi.com
COPD is a heterogeneous disease, and its acute exacerbation is a major prognostic factor.
We used cluster analysis to predict COPD exacerbation due to subtypes of mild–moderate …

Mechanisms and impact of the frequent exacerbator phenotype in chronic obstructive pulmonary disease

JA Wedzicha, SE Brill, JP Allinson, GC Donaldson - BMC medicine, 2013 - Springer
Exacerbations of chronic obstructive pulmonary disease (COPD) are important events that
carry significant consequences for patients. Some patients experience frequent …