Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and
asthma, affect millions of people all over the world. Cyclic adenosine monophosphate …

Phosphodiesterases hydrolyse intracellular cyclic nucleotides, cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) into inactive 5 …

Abstract Phosphodiesterase 4 (PDE4) is member of the growing family of proteins that
regulate the intracellular concentrations of cyclic AMP and cyclic GMP. Earliest described …

Phosphodiesterases (PDEs) are a family of enzymes which catalyse the metabolism of the
intracellular cyclic nucleotides, c-AMP and c-GMP that are expressed in a variety of cell …

Introduction: Phosphodiesterase (PDE) inhibitors modulate lung inflammation and cause
bronchodilation by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway …

Introduction Phosphodiesterases (PDEs) are isoenzymes ubiquitously expressed in the
lungs where they catalyse cyclic adenosine monophosphate (cAMP) and cyclic guanosine …

Phosphodiesterases (PDEs) are a superfamily of enzymes that catalyze the breakdown of
cAMP and/or cyclic guanosine monophosphate (GMP) to their inactive form. PDE4 is the …

Xanthines like theophylline have long been recognised as being effective drugs for the
treatment of asthma and chronic obstructive pulmonary disease (COPD). They are of interest …

Phosphodiesterases (PDE) belong to an important family of proteins that regulate the
intracellular levels of cyclic nucleotide second messengers. Targeting PDE with selective …

Phosphodiesterases (PDE) are a family of enzymes responsible for the metabolism of the
intracellular second messengers cyclic AMP and cyclic GMP. PDE4 is a cyclic AMP specific …