Over the past decade, the vast amount of information generated through structural and
biophysical studies of GPCRs has provided unprecedented mechanistic insight into the …

Highlights•Using multiple labelling strategies, NMR spectroscopy provides insights into the
dynamic nature of several class A GPCRs.•Receptors populate a range of states that are in …

The membrane bilayer has a significant influence over the proteins embedded within it. G
protein-coupled receptors (GPCRs) form a large group of membrane proteins with a vast …

The first crystal structure of a G protein‐coupled receptor (GPCR) was that of the bovine
rhodopsin, solved in 2000, and is a light receptor within retina rode cells that enables vision …

G protein–coupled receptors (GPCRs) function as receptors for various neurotransmitters,
hormones, cytokines, and metabolites. GPCR ligands impart differing degrees of signaling in …

Experimental observations of the dependence of function and organization of G protein-
coupled receptors (GPCRs) on their lipid environment have stimulated new quantitative …

Highlights•Allosteric GPCR drug discovery is gaining increasing attention.•Lipid bilayer
plays a unique role in the allosteric sites of GPCRs.•The role of lipid bilayer in allosteric sites …

Functioning of G protein-coupled receptors (GPCRs) is tightly linked to the membrane
environment, but a molecular level understanding of the modulation of GPCR by membrane …

Great progress has been made over the past decade in understanding the structural,
functional, and pharmacological diversity of lipid GPCRs. From the first determination of the …

G protein‐coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …