RNA-seq protocols that focus on transcript termini are well suited for applications in which
template quantity is limiting. Here we show that, when applied to end-sequencing data …

Advancing RNA-Seq analysis | Nature Biotechnology Skip to main content Thank you for
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Boosting the power of single-cell analysis | Nature Biotechnology Skip to main content Thank
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Initial high-throughput RNA sequencing (RNA-Seq) experiments have revealed a complex
and dynamic transcriptome, but because it samples transcripts in proportion to their …

How deep is enough in single-cell RNA-seq? | Nature Biotechnology Skip to main content
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Background Early application of second-generation sequencing technologies to transcript
quantitation (RNA-seq) has hinted at a vast mammalian transcriptome, including transcripts …

The transcriptome encompasses a range of species including messenger RNA, and other
noncoding RNA such as rRNA, tRNA, and short and long noncoding RNAs. Due to the huge …

To the Editor—As single-cell RNA sequencing (scRNA-seq) becomes widespread,
accessible and scalable computational pipelines for data analysis are needed. We introduce …

Background Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool to dissect cell-
specific effects of drug treatment in complex tissues. This application requires high levels of …

The recent rapid spread of single cell RNA sequencing (scRNA-seq) methods has created a
large variety of experimental and computational pipelines for which best practices have not …