Abstract Purpose of Review To summarize key advances in our understanding of the role of
interleukin 17A (IL-17A) in the pathogenesis of hypertension and highlight important areas …

Abstract Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the
immune system, predominantly Th17 and γδ lymphocytes. In this paper, we review the role …

Hypertension is now considered as an inflammatory disease, and the kidney is a key end-
organ target. Experimental and clinical studies suggest that interleukin 17A (IL-17A) is a …

Current knowledge suggests that hypertension is in part mediated by immune mechanisms.
Both interleukin (IL)-23 and IL-17 are up-regulated in several experimental hypertensive …

We have shown previously that T cells are required for the full development of angiotensin II–
induced hypertension. However, the specific subsets of T cells that are important in this …

An important link exists between hypertension and inflammation. Hypertensive patients
present elevated circulating levels of proinflammatory cytokines, including interleukin-17A …

Inflammatory cytokines play a major role in the pathophysiology of hypertension. The
authors previously showed that genetic deletion of interleukin (IL)-17A results in blunted …

Angiotensin II–induced hypertension is associated with an increase in T-cell production of
interleukin-17A (IL-17A). Recently, we reported that IL-17A−/− mice exhibit blunted …

IL (Interleukin)-17A is a key inflammatory mediator contributing to chronic tissue
inflammation. The present study sought to determine whether IL-17A plays a role in …

T cells participate in angiotensin II (Ang II)–induced hypertension. However, the specific
subsets of T cells that are important in the end-organ damage are unknown. T-helper 17 …