The immune system is constantly protecting its host from the invasion of pathogens and the
development of cancer cells. The specific CD8+ T-cell immune response against virus …

Understanding the mechanisms involved in the activation of an immune response is
essential to many fields in human health, including vaccine development and personalized …

The binding of bound peptide ligands to major histocompatibility complex (MHC) molecules
plays a key role in the activation of normal immune responses and is an intricate theoretical …

The class I major histocompatibility complex (MHC) is capable of binding peptides derived
from intracellular proteins and displaying them at the cell surface. The recognition of these …

The binding of peptide fragments of antigens to class II MHC proteins is a crucial step in
initiating a helper T cell immune response. The discovery of these peptide epitopes is …

Major histocompatibility complex (MHC) proteins present peptides on the cell surface for T
cell surveillance. Reliable in silico prediction of which peptides would be presented and …

Motivation The identification of T-cell epitopes has many profound translational applications
in the areas of transplantation, disease diagnosis, vaccine/therapeutic protein development …

T cell receptor (TCR) recognition of foreign peptides presented by major histocompatibility
complex (MHC) proteins is a crucial step in triggering the adaptive immune response …

There is long-standing interest in accurately modeling the structural features of peptides
bound and presented by class I MHC proteins. This interest has grown with the advent of …

The recognition of peptides bound to class I major histocompatibility complex (MHC-I)
receptors by T-cell receptors (TCRs) is a determinant of triggering the adaptive immune …