[HTML][HTML] Cytokine “fine tuning” of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies

T Russell, C Bridgewood, H Rowe, A Altaie… - Seminars in …, 2021 - Springer
A curious feature of axial disease in ankylosing spondylitis (AS) and related non-
radiographic axial spondyloarthropathy (nrAxSpA) is that spinal inflammation may ultimately …

Complexity of enthesitis and new bone formation in ankylosing spondylitis: current understanding of the immunopathology and therapeutic approaches

M Kusuda, N Haroon, A Nakamura - Modern Rheumatology, 2022 - academic.oup.com
Despite increasing availability of treatments for spondyloarthritis (SpA) including tumour
necrosis factor (TNF) and interleukin-17 (IL-17) inhibitors, there is no established treatment …

Advances in understanding the pathophysiology of spondyloarthritis

RJ Lories - Best Practice & Research Clinical Rheumatology, 2018 - Elsevier
Progressive understanding of the underlying pathophysiology of axial spondyloarthritis has
successfully translated into innovative therapeutic strategies and successful management of …

Pathophysiology and immunolgical basis of axial spondyloarthritis

MGH van de Sande, D Elewaut - Best Practice & Research Clinical …, 2023 - Elsevier
Over the recent years the wider availability and application of state-of-the-art immunological
technologies greatly advanced the insight into the mechanisms that play an important role in …

[HTML][HTML] New insights into IL‑17/IL‑23 signaling in ankylosing spondylitis

BA Chisălău, LI Crînguș, FA Vreju… - Experimental and …, 2020 - spandidos-publications.com
Ankylosing spondylitis (AS) is a progressive common autoimmune inflammatory disease,
part of the spondylarthritis group, characterized, besides clinical spinal and peripheral joint …

[HTML][HTML] Enthesitis: much more than focal insertion point inflammation

A Watad, RJ Cuthbert, H Amital… - Current rheumatology …, 2018 - Springer
Abstract Purpose of Review Recognition of the importance of enthesitis as the pivotal
pathological process underpinning spondyloarthropathies (SpA) has increased in recent …

Interleukin‐23 pathway at the enthesis: The emerging story of enthesitis in spondyloarthropathy

C Bridgewood, K Sharif, J Sherlock… - Immunological …, 2020 - Wiley Online Library
The inflammatory disorders collectively termed the seronegative spondyloarthropathies
(SpA) include ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, the …

Entheses and bones in spondyloarthritis: 2008 Annual research and education meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN)

RA Colbert, AA Deodhar, D Fox… - The Journal of …, 2009 - jrheum.org
The Spondyloarthritis Research and Therapy Network (SPARTAN), founded in 2003 to
promote research, education, and treatment of ankylosing spondylitis (AS) and related forms …

Recent updates in the immunopathology of type 3 immunity-mediated enthesitis

A Nakamura, N Haroon - Current Rheumatology Reports, 2021 - Springer
Abstract Purpose of Review Enthesitis is a cardinal feature of spondyloarthritis (SpA).
Despite increasing available treatments, challenges remain in adequately controlling …

The bone marrow side of axial spondyloarthritis

D Mauro, S Gandolfo, E Tirri, G Schett… - Nature Reviews …, 2023 - nature.com
Spondyloarthritis (SpA) is characterized by the infiltration of innate and adaptive immune
cells into entheses and bone marrow. Molecular, cellular and imaging evidence …