Pathobiological mechanisms of peritoneal adhesions: The mesenchymal transition of rat peritoneal mesothelial cells induced by TGF-β1 and IL-6 requires activation of …

X Jin, S Ren, E Macarak, J Rosenbloom - Matrix Biology, 2016 - Elsevier
Peritoneal adhesions, primarily caused by surgical procedures, are the leading cause of
pelvic pain, bowel obstruction, and infertility. TGF-β1 and IL-6 have been found to be …

[HTML][HTML] TGF-β1 promotes transition of mesothelial cells into fibroblast phenotype in response to peritoneal injury in a cell culture model

P Falk, E Angenete, M Bergström… - International Journal of …, 2013 - Elsevier
Background Peritoneal adhesions are a clinical problem. A key to the understanding of
peritoneal adhesions is to study the healing of mesothelial cells within the peritoneal cavity …

Mesothelial‐to‐mesenchymal transition in the pathogenesis of post‐surgical peritoneal adhesions

P Sandoval, JA Jiménez‐Heffernan… - The Journal of …, 2016 - Wiley Online Library
Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs,
and the parietal peritoneum, which may appear following surgery, infection or …

Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells

P Patel, J West-Mays, M Kolb, JC Rodrigues, CM Hoff… - Matrix Biology, 2010 - Elsevier
Platelet derived growth factor (PDGF) is involved in wound healing in various organ
systems. Its potential role in the context of peritoneal injury following long-term peritoneal …

[HTML][HTML] Macrophages induce the adhesion phenotype in normal peritoneal fibroblasts

JC White, ZL Jiang, MP Diamond, GM Saed - Fertility and sterility, 2011 - Elsevier
OBJECTIVE: To determine whether macrophages, exposed to hypoxia, stimulate primary
cultures of fibroblasts to acquire the adhesion phenotype. The adhesion phenotype has …

TGF-β system: the principal profibrotic mediator of peritoneal adhesion formation

N Chegini - Seminars in reproductive medicine, 2008 - thieme-connect.com
Whether induced by infection, inflammation, ischemia, and/or surgical injury, peritoneal
adhesions are the leading cause of pelvic pain, bowel obstruction, and infertility. Although …

[HTML][HTML] Mechanisms of peritoneal mesothelial cells in peritoneal adhesion

R Wang, T Guo, J Li - Biomolecules, 2022 - mdpi.com
A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to
the peritoneum. The formation of PAs can induce a variety of clinical diseases. However …

[HTML][HTML] Hypoxia, cytokines and stromal recruitment: parallels between pathophysiology of encapsulating peritoneal sclerosis, endometriosis and peritoneal …

RB Wilson - Pleura and peritoneum, 2018 - degruyter.com
Peritoneal response to various kinds of injury involves loss of peritoneal mesothelial cells
(PMC), danger signalling, epithelial-mesenchymal transition and mesothelial-mesenchymal …

Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in mesothelial cells and their regulation by transforming growth factor‐β1

C Ma, RW Tarnuzzer, N Chegini - Wound repair and …, 1999 - Wiley Online Library
Tissue injury and pelvic inflammation often results in peritoneal scar tissue formation. The
objective of this study was to determine whether mesothelial cells which line the peritoneal …

Disruption of the integrity of human peritoneal mesothelium by interleukin-1β and tumor necrosis factor-α

S Stadlmann, R Raffeiner, A Amberger, R Margreiter… - Virchows Archiv, 2003 - Springer
Inflammatory and neoplastic disease processes of the abdominal cavity are frequently
associated with disruption of the integrity of the peritoneal mesothelium. In the present study …