Aberrations in the adult hippocampal neurogenesis in AD patients include dysfunctional
maturation indicated by accumulated number of immature neurons. The hippocampus …

Neurogenesis occurs in the subventricular zone and the sub-granular layer of the
hippocampus and is thought to take place in 5 stages, including proliferation, differentiation …

AIMS: Hippocampal cholinergic hypofunction is known to be involved in the cognitive deficits
of Alzheimer's disease, but the detailed mechanisms remain to be elucidated. In order to …

Background: Cholinergic cell loss in the basal forebrain, the major source of hippocampal
cholinergic projections, has been implicated in Alzheimer's disease. Objective: To examine …

Background The degeneration of the cholinergic circuit from the basal forebrain to the
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …

The basal forebrain cholinergic system is widely assumed to control cortical functions via
non-synaptic transmission of a single neurotransmitter, acetylcholine. Yet, using immune …

Hippocampus-mediated learning enhances neurogenesis in the adult dentate gyrus (DG),
and this process has been suggested to be involved in memory formation. The hippocampus …

Cholinergic deficits occur in the aged hippocampus and they are significant in Alzheimer's
disease. Using stereological and biochemical approaches, we characterized the cholinergic …

The CHAT gene encodes choline acetyltransferase, which is an enzyme responsible for the
biosynthesis of the neurotransmitter acetylcholine in the brain. This study collected structural …

BACKGROUND: Exciting preliminary work indicates an increase in progenitor activity in the
subgranular zone of the dentate gyrus of people with Alzheimer's disease (AD) compared to …