During tissue inflammation, immune cells infiltrate the interstitial space of target organs,
where they sense and adapt to local environmental stimuli. Such stimuli include not only …

The skin can serve as an interstitial Na+ reservoir. Local tissue Na+ accumulation increases
with age, inflammation and infection. This increased local Na+ availability favors pro …

Sodium intake is undoubtedly indispensable for normal body functions but can be
detrimental when taken in excess of dietary requirements. The consequences of excessive …

Immune cells regulate a hypertonic microenvironment in the skin; however, the biological
advantage of increased skin Na+ concentrations is unknown. We found that Na+ …

The Western diet is rich in salt, and a high salt diet (HSD) is suspected to be a risk factor for
cardiovascular diseases. It is now widely accepted that an experimental HSD can stimulate …

Dysregulation of sodium (Na+) balance is a major cause of hypertensive cardiovascular
disease. The current dogma is that interstitial Na+ readily equilibrates with plasma and that …

Our understanding of Na+ homeostasis has recently been reshaped by the notion of skin as
a depot for Na+ accumulation in multiple cardiovascular diseases and risk factors. The …

Background The adverse effect of excessive salt intake has been recognized in decades.
Researchers have mainly focused on the association between salt intake and hypertension …

High dietary sodium intake triggers increased blood pressure (BP). Animal studies show that
dietary salt loading results in dermal Na+ accumulation and lymphangiogenesis mediated …

The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can
stimulate immunity through the nuclear factor of activated T cells 5 (Nfat5)–signaling …