Targeting natural killer cells in solid tumors

G Habif, A Crinier, P André, E Vivier… - Cellular & molecular …, 2019 - nature.com
Natural killer (NK) cells are innate lymphoid cells endowed with cytolytic activity and a
capacity to secrete cytokines and chemokines. Several lines of evidence suggest that NK …

Natural killer cells: a review of biology, therapeutic potential and challenges in treatment of solid tumors

K Choucair, JR Duff, CS Cassidy, MT Albrethsen… - Future …, 2019 - Future Medicine
Natural killer (NK) cells lead immune surveillance against cancer and early elimination of
small tumors. Owing to their ability to engage tumor targets without the need of specific …

[HTML][HTML] Targeting natural killer cells for tumor immunotherapy

C Zhang, Y Hu, C Shi - Frontiers in immunology, 2020 - frontiersin.org
Natural killer (NK) cells are important innate cytotoxic lymphocytes with a rapid and efficient
capacity to recognize and kill tumor cells. In recent years, adoptive transfer of autologous-or …

Roles of natural killer cells in immunity to cancer, and applications to immunotherapy

NK Wolf, DU Kissiov, DH Raulet - Nature Reviews Immunology, 2023 - nature.com
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Prospects for the use of NK cells in immunotherapy of human cancer

HG Ljunggren, KJ Malmberg - Nature Reviews Immunology, 2007 - nature.com
Current insights into the molecular specificities that regulate natural killer (NK)-cell function
suggest that it might be possible to design NK-cell-based immunotherapeutic strategies …

[HTML][HTML] Natural killer cell-based therapies targeting cancer: possible strategies to gain and sustain anti-tumor activity

CIM Dahlberg, D Sarhan, M Chrobok, AD Duru… - Frontiers in …, 2015 - frontiersin.org
Natural killer (NK) cells were discovered 40 years ago, by their ability to recognize and kill
tumor cells without the requirement of prior antigen exposure. Since then, NK cells have …

Natural killer cells and solid tumors

A Stojanovic, A Cerwenka - Journal of innate immunity, 2011 - karger.com
Natural killer (NK) cells play an important role in the innate immune response against
cancer, in particular in the elimination of tumor metastases and small tumors. NK cell …

[HTML][HTML] Natural killer cells: the linchpin for successful cancer immunotherapy

KA Shaver, TJ Croom-Perez, AJ Copik - Frontiers in immunology, 2021 - frontiersin.org
Cancer immunotherapy is a highly successful and rapidly evolving treatment modality that
works by augmenting the body's own immune system. While various immune stimulation …

Natural killer cell‐based immunotherapy in cancer: current insights and future prospects

T Sutlu, E Alici - Journal of internal medicine, 2009 - Wiley Online Library
As our understanding of the molecular mechanisms governing natural killer (NK) cell activity
increases, their potential in cancer immunotherapy is growing increasingly prominent. This …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …