Cytokine and cytokine receptors are important regulators of hematopoiesis. Hematopoietic
stem cells (HSCs) and progenitors differentiate into the myeloid or lymphoid lineage in …

Haemopoietic cytokines regulate haemopoietic cell function via specific cell surface
receptors. These receptors are members of a large superfamily of transmembrane proteins …

Publisher Summary This chapter outlines the role of cytokine receptor signaling in the
regulation and maturation of myeloid cells: erythrocytes, macrophages, granulocytes …

Publisher Summary This chapter discusses the characteristics that define the structure and
composition of the receptors and their ability to bind ligand and transduce signals, known as …

The growth and differentiation of hematopoietic stem cells to form the vast repertoire of
mature blood cells that exists in vivo is orchestrated by an array of intercellular signals …

The binding of haemopoietic growth factors and cytokines to specific receptors triggers a
cascade of intracellular events which results in cell proliferation and differentiation. The …

The production of blood cells is regulated by the action of external factors, cytokines, that
can be released by many cell types. In the first place, a population of multipotent stem cells …

▪ Abstract The cytokine receptor superfamily is characterized by structural motifs in the
exoplasmic domain and by the absence of catalytic activity in the cytosolic segment …

The cytokine receptor superfamily is a group of transmembrane proteins, characterized by a
common extracellular structure-two barrels composed of seven [beta] strands each. Over the …

Haematopoiesis is regulated through the interaction of a variety of haematopoietic growth
factors with their cognate receptors (Clark and Kamen, 1987; Metcalf, 1989; Nicola, 1989; …