[HTML][HTML] ADSC-exo@ MMP-PEG smart hydrogel promotes diabetic wound healing by optimizing cellular functions and relieving oxidative stress

T Jiang, S Liu, Z Wu, Q Li, S Ren, J Chen, X Xu… - Materials Today Bio, 2022 - Elsevier
Diabetic wound complications are financially costly and difficult to heal in worldwide.
Whereas the therapies of diabetic wound, such as wound dressing, endocrine therapy or …

Adipose‐Derived Mesenchymal Stem Cell‐Derived Exosomes Biopotentiated Extracellular Matrix Hydrogels Accelerate Diabetic Wound Healing and Skin …

Y Song, Y You, X Xu, J Lu, X Huang, J Zhang… - Advanced …, 2023 - Wiley Online Library
Wound healing is an urgent clinical challenge, particularly in the case of chronic wounds.
Traditional approaches to wound healing have limited therapeutic efficacy due to lengthy …

Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing

N Hu, Z Cai, X Jiang, C Wang, T Tang, T Xu, H Chen… - Acta biomaterialia, 2023 - Elsevier
Accumulating reports indicate that adipose-derived stem cell (ADSC)-originating exosomes
(ADSC-Exos) provide a potential strategy for diabetic wound repair. However, the …

A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing

X Geng, Y Qi, X Liu, Y Shi, H Li, L Zhao - Biomaterials Advances, 2022 - Elsevier
Chronic diabetic wound injury is a serious syndrome of diabetes, and the treatment of this
syndrome is of great significance. Owing to metabolic abnormalities, diabetic wounds are …

Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways

J Wang, H Wu, Y Peng, Y Zhao, Y Qin, Y Zhang… - Journal of …, 2021 - Springer
Refractory diabetic wounds can cause persistent inflammation and delayed healing due to
hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs …

Investigation on repairing diabetic foot ulcer based on 3D bio-printing Gel/dECM/Qcs composite scaffolds

Y Zhong, H Ma, Y Lu, L Cao, YY Cheng, X Tang, H Sun… - Tissue and Cell, 2023 - Elsevier
Diabetic foot ulcers are one of the most serious of the numerous complications of diabetes
mellitus, causing great physical trauma and financial stress to patients, and accelerating …

Umbilical cord-derived mesenchymal stem cell-derived exosomes combined pluronic F127 hydrogel promote chronic diabetic wound healing and complete skin …

J Yang, Z Chen, D Pan, H Li, J Shen - International journal of …, 2020 - Taylor & Francis
Purpose Chronic refractory wounds are a multifactorial comorbidity of diabetes mellitus with
the characteristic of impaired vascular networks. Currently, there is a lack of effective …

GMSC-derived exosomes combined with a chitosan/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model

Q Shi, Z Qian, D Liu, J Sun, X Wang, H Liu, J Xu… - Frontiers in …, 2017 - frontiersin.org
Background: Delayed wound healing in diabetic patients is one of the most challenging
complications in clinical medicine, as it poses a greater risk of gangrene, amputation and …

Preparation of exosomes encapsulated nanohydrogel for accelerating wound healing of diabetic rats by promoting angiogenesis

Y Zhang, P Zhang, X Gao, L Chang, Z Chen… - Materials Science and …, 2021 - Elsevier
Exosomes derived from human umbilical cord mesenchymal stem cells (HUCMSCs) were
helpful for injury repair, but whether HUCMSCs-derived exosomes could be encapsulated in …

Exosomes from adipose stem cells promote diabetic wound healing through the eHSP90/LRP1/AKT axis

S Ren, J Chen, J Guo, Y Liu, H Xiong, B Jing, X Yang… - Cells, 2022 - mdpi.com
Oxidative damage is a critical cause of diabetic wounds. Exosomes from various stem cells
could promote wound repair. Here, we investigated the potential mechanism by which …