[HTML][HTML] Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD …

CH Wallace, G Oliveros, L Xie, P Serrano… - Scientific Reports, 2024 - nature.com
Alzheimer's disease (AD) is the major form of dementia prevalent in older adults and with a
high incidence in females. Identification of early biomarkers is essential for preventive …

[HTML][HTML] Dysregulated gene-associated biomarkers for Alzheimer's disease and aging

M Li, R Geng, C Li, F Meng, H Zhao, J Liu… - Translational …, 2021 - degruyter.com
Abstract Alzheimer's disease (AD), the most common type of dementia, is a
neurodegenerative disorder with a hidden onset, including difficult early detection and …

Chronic Estradiol Administration During the Early Stage of Alzheimer's Disease Pathology Rescues Adult Hippocampal Neurogenesis and Ameliorates Cognitive …

J Zheng, K Liang, X Wang, X Zhou, J Sun… - Molecular …, 2017 - Springer
Alzheimer's disease (AD) is the leading cause of dementia and has become an important
public health concern. Accumulating evidence indicates that estradiol can both facilitate and …

[HTML][HTML] Transcriptional, behavioral and biochemical profiling in the 3xTg-AD mouse model reveals a specific signature of amyloid deposition and functional decline in …

W Yin, N Cerda-Hernández… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD)-related degenerative decline is associated to the presence of
amyloid beta (Aβ) plaque lesions and neuro fibrillary tangles (NFT). However, the precise …

[HTML][HTML] A systematic review for the development of Alzheimer's disease in in vitro models: a focus on different inducing agents

M Prajapat, G Kaur, G Choudhary, P Pahwa… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common progressive neurodegenerative disease and
is associated with dementia. Presently, various chemical and environmental agents are …

[HTML][HTML] ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

CE Evans, JS Miners, G Piva, CL Willis, DM Heard… - Acta …, 2020 - Springer
Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of
later life dementia, including Alzheimer's disease (AD). The classical renin–angiotensin …

[HTML][HTML] Early and sustained altered expression of aging-related genes in young 3xTg-AD mice

V Gatta, M D'Aurora, A Granzotto, L Stuppia… - Cell death & …, 2014 - nature.com
Alzheimer's disease (AD) is a multifactorial neurological condition associated with a genetic
profile that is still not completely understood. In this study, using a whole gene microarray …

[HTML][HTML] Sex differences in hippocampal β-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens

YT Hu, XL Chen, YN Zhang, H McGurran… - Frontiers in …, 2023 - frontiersin.org
Introduction Epidemiological studies show that women have a higher prevalence of
Alzheimer's disease (AD) than men. Peripheral estrogen reduction during aging in women is …

[HTML][HTML] Inhibition of early growth response 1 in the hippocampus alleviates neuropathology and improves cognition in an Alzheimer model with plaques and tangles

X Qin, Y Wang, HK Paudel - The American journal of pathology, 2017 - Elsevier
A sporadic form of Alzheimer disease (AD) and vascular dementia share many risk factors,
and their pathogenic mechanisms are suggested to be related. Transcription factor early …

[HTML][HTML] Females exhibit higher GluA2 levels and outperform males in active place avoidance despite increased amyloid plaques in TgF344-Alzheimer's rats

O Chaudry, K Ndukwe, L Xie, M Figueiredo-Pereira… - Scientific Reports, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is most prevalent
in females. While estrogen provides neuroprotection in females, sex mediated differences in …