When aging, melanin in human retinal pigment epithelium (RPE) undergoes oxidative
modifications, which increase its photoreactivity and reduce its antioxidant capacity …

Short wavelength visible light is viewed as the main agent responsible for oxidative
modification of melanin in the human retinal pigment epithelium (RPE). The aim of this …

The retinal pigment epithelium (RPE) is a monolayer of highly pigmented cells lining the
inner aspect of Bruch's membrane. This pigmentation is due to eumelanin and a possible …

In this work, we examined photoreactivity of synthetic eumelanins, formed by autooxidation
of DOPA, or enzymatic oxidation of 5, 6‐dihydroxyindole‐2‐carboxylic acid and synthetic …

Melanin, particularly eumelanin, is commonly viewed as an efficient antioxidant and
photoprotective pigment. Nonetheless, the ability of melanin to photogenerate reactive …

Melanosomes of the retinal pigment epithelium (RPE) are relatively long‐lived organelles
that are theoretically susceptible to changes induced by exposure to visible light. Here …

Photoexcited melanin from retinal pigment epithelium (RPE) has been shown to induce
photo‐oxidation of ascorbate with concomitant generation of hydrogen peroxide. The aim of …

With aging, retinal pigment epithelium melanosomes, by fusion with the age pigment
lipofuscin, form complex granules called melanolipofuscin. Lipofuscin granules may contain …

With increasing age, there is an observable loss of melanin in retinal pigment epithelial
(RPE) cells. It is possible that degradation of the pigment contributes to the pathogenesis of …

Even though melanin is commonly viewed as natural photoprotectant, the pigment
demonstrates residual photoreactivity, which under certain conditions could contribute to …