β-blockers in the management of hypertension: focus on nebivolol

D Wojciechowski, V Papademetriou - Expert review of …, 2008 - Taylor & Francis
Hypertension is a major cardiovascular risk factor but most patients remain asymptomatic for
many years. Successful therapy not only needs to be effective, it also needs to be well …

Nebivolol efficacy and safety in patients with stage I‐II hypertension

M Greathouse - … Cardiology: An International Indexed and Peer …, 2010 - Wiley Online Library
Background Nebivolol is a novel, β1‐adrenergic receptor blocker with vasodilatory
properties mediated through activation of the L‐arginine/nitric oxide pathway. Hypothesis …

Nebivolol: A third-generation β-blocker for hypertension

JWM Cheng - Clinical therapeutics, 2009 - Elsevier
Background: Nebivolol is a third-generation β1-selective β-blocker that is approved for the
treatment of hypertension. Objective: This article reviews the clinical pharmacology of …

Nebivolol, a beta blocker of the 3rd generation: modern therapy of arterial hypertension. Results of a multicenter observation study

J Von Fallois, HD Faulhaber - Praxis, 2001 - europepmc.org
Background Nebivolol represents a therapeutic class of beta blockers with high beta 1
selectivity and modulatory effect on vascular reactions by releasing nitric oxide (NO) from …

Treatment of ambulatory hypertensives with nebivolol or hydrochlorothiazide alone and in combination: a randomized, double-blind, placebo-controlled, factorial …

Y Lacourciere, J Lefebvre, L Poirier… - American journal of …, 1994 - academic.oup.com
This placebo-controlled multifactorial design trial assessed the antihypertensive efficacy of
nebivolol, a novel cardioselective β1-blocker with vasodilating properties, and …

[HTML][HTML] Beneficial effects of nebivolol in comparison with atenolol on safety and tolerability in essential hypertension

VV Bhosale, SC Inamdar, VB Karande… - Journal of clinical and …, 2014 - ncbi.nlm.nih.gov
Abstract Introduction: Hypertension,“The silent killer” is a multifactorial disorder which is
asymptomatic and if left untreated leads to lethal complications. Nebivolol is a third …

A comparison of atenolol and nebivolol in isolated systolic hypertension

Z Dhakam, CM McEniery, T Burton… - Journal of …, 2008 - journals.lww.com
Objectives Some β-blockers are less effective in reducing central blood pressure than other
antihypertensive drugs, which may explain the higher rate of events in subjects randomized …

Haemodynamic effects and pharmacokinetics of oral d-and l-nebivolol in hypertensive patients

A Himmelmann, T Hedner, E Snoeck… - European journal of …, 1996 - Springer
Objective: Nebivolol is a selective β 1-adrenergic receptor blocker possessing an ancillary
vasodilating effect. The objective of the present study was to study the haemodynamic and …

Blood pressure-lowering effect of nebivolol in hypertensive patients with type 2 diabetes mellitus: the YESTONO study

AC Schmidt, C Graf, K Brixius, J Scholze - Clinical drug investigation, 2007 - Springer
Background: Effective blood pressure (BP)-lowering therapy is regarded as the most
important intervention in diabetes mellitus. Nebivolol is commonly used for the treatment of …

Nebivolol versus metoprolol in the treatment of hypertension

O Uhlíř, M Fejfuša, K Havranek, K Lefflerová… - Drug Investigation, 1991 - Springer
The efficacy and safety of 2 cardioselective β-blockers, metoprolol 100mg twice daily and
nebivolol 5mg once daily, were compared in 155 patients with mild to moderate …