It remains unclear how exercise, as an entropic event, brings benefit against human aging.
Here we examined longitudinal changes of p16 Ink4a+ senescent cells in skeletal muscle of …

Macrophages are involved in skeletal muscle repair through pro-inflammatory and
alternative functions. We tested the hypothesis that aging alters the abundance and …

Cellular senescence has emerged as a significant and potentially tractable mechanism of
aging and multiple aging‐related conditions. Biomarkers of senescent cell burden, including …

The aim of the present study was to determine if the training status decreases inflammation,
slows down senescence, and preserves telomere health in skeletal muscle in older …

Abstract p16 INK4a expression is a robust biomarker of senescence for stem cells in human
tissues. Here we examined the effect of exercise intensity on in vivo senescence in skeletal …

The current model for repair of damaged tissue includes immune cells, mediating the
progression from a pro-inflammatory to an anti-inflammatory environment. How this process …

We propose the beneficial effects of exercise are in part mediated through the prevention
and elimination of senescent cells. Exercise counters multiple forms of age-related …

Aging coincides with a higher frequency of muscle disuse and recovery events (due to
illness, surgery, pain) that are likely to lead to rapid loss of muscle mass and strength. Full …

The impact of aging on the cytokine response of human skeletal muscle to exercise‐induced
injury remains poorly understood. We enrolled physically active, young (23–35 years old, n …

The pro-and anti-inflammatory macrophages are associated with insulin sensitivity and
skeletal muscle regeneration. Infiltrating macrophages in skeletal muscle during a period of …