Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells
Platelet deficiency, known as thrombocytopenia, can cause hemorrhage and is treated with
platelet transfusions. We developed a system for the production of platelet precursor cells …
platelet transfusions. We developed a system for the production of platelet precursor cells …
Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors
AL Evans, A Dalby, HR Foster, D Howard… - Blood …, 2021 - ashpublications.org
The production of in vitro–derived platelets has great potential for transfusion medicine.
Here, we build on our experience in the forward programming (FoP) of human pluripotent …
Here, we build on our experience in the forward programming (FoP) of human pluripotent …
The heterogeneity of megakaryocytes and platelets and implications for ex vivo platelet generation
C Liu, B Huang, H Wang, J Zhou - Stem Cells Translational …, 2021 - academic.oup.com
Platelets, the chief effector of hemostasis, are small anucleate blood cells generated from
megakaryocytes (MKs), and the defects in platelet production or function lead to a variety of …
megakaryocytes (MKs), and the defects in platelet production or function lead to a variety of …
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
The production of megakaryocytes (MKs)—the precursors of blood platelets—from human
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …
pluripotent stem cells (hPSCs) offers exciting clinical opportunities for transfusion medicine …
Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs
M Sone, S Nakamura, S Umeda, H Ginya, M Oshima… - Stem cell reports, 2021 - cell.com
Platelet transfusions are critical for severe thrombocytopenia but depend on blood donors.
The shortage of donors and the potential of universal HLA-null platelet products have …
The shortage of donors and the potential of universal HLA-null platelet products have …
Efficient generation of megakaryocytes from human induced pluripotent stem cells using food and drug administration-approved pharmacological reagents
Megakaryocytes (MKs) are rare hematopoietic cells in the adult bone marrow and produce
platelets that are critical to vascular hemostasis and wound healing. Ex vivo generation of …
platelets that are critical to vascular hemostasis and wound healing. Ex vivo generation of …
[HTML][HTML] Forming megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors
K Cullmann, M Jahn, M Spindler, F Schenk… - Research and Practice …, 2021 - Elsevier
Background Platelets are small anucleate cells that circulate in the blood in a resting state
but can be activated by external cues. In case of need, platelets from blood donors can be …
but can be activated by external cues. In case of need, platelets from blood donors can be …
[HTML][HTML] Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells
S Nakamura, N Takayama, S Hirata, H Seo, H Endo… - Cell stem cell, 2014 - cell.com
The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs.
To address this issue, we developed a clinically applicable strategy for the derivation of …
To address this issue, we developed a clinically applicable strategy for the derivation of …
[HTML][HTML] Platelet production system using an immortalized megakaryocyte cell line derived from human pluripotent stem cells
S Nakamura, N Takayama, H Nakauchi, K Eto - Blood, 2011 - Elsevier
Abstract MRG-1 Human induced pluripotent stem cells (hiPSCs) are a promising source of
blood cells, including platelets, for transfusion. However, there remains a need for: 1) a …
blood cells, including platelets, for transfusion. However, there remains a need for: 1) a …
Induced pluripotent stem cell–derived megakaryocytes and platelets for disease modeling and future clinical applications
Platelets, derived from megakaryocytes, are anucleate cytoplasmic discs that circulate in the
blood stream and play major roles in hemostasis, inflammation, and vascular biology …
blood stream and play major roles in hemostasis, inflammation, and vascular biology …