Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals
PC Prokopiou, N Engels-Domínguez, KV Papp… - Nature …, 2022 - nature.com
Animal and human imaging research reported that the presence of cortical Alzheimer's
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …
Disease's (AD) neuropathology, beta-amyloid and neurofibrillary tau, is associated with …
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
Several autopsy studies recognize the locus coeruleus (LC) as the initial site of
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
hyperphosphorylated TAU aggregation, and as the number of LC neurons harboring TAU …
[HTML][HTML] Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease
Abnormally phosphorylated tau, an indicator of Alzheimer's disease, accumulates in the first
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However …
decades of life in the locus coeruleus (LC), the brain's main noradrenaline supply. However …
Early alteration of the locus coeruleus in phenotypic variants of Alzheimer's disease
P Olivieri, J Lagarde, S Lehericy… - Annals of clinical …, 2019 - Wiley Online Library
Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with
tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC‐I) on 3T MRI to …
tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC‐I) on 3T MRI to …
Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease
Introduction Autopsy studies recognize the locus coeruleus (LC) as one of the first sites
accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic …
accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic …
Magnetic resonance imaging Locus Coeruleus abnormality in amnestic Mild Cognitive Impairment is associated with future progression to dementia
Background and purpose Human neuropathological studies indicate that the pontine
nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's …
nucleus Locus Coeruleus (LC) undergoes significant and early degeneration in Alzheimer's …
Brain amyloid-β burden is associated with disruption of intrinsic functional connectivity within the medial temporal lobe in cognitively normal elderly
The medial temporal lobe is implicated as a key brain region involved in the pathogenesis of
Alzheimer9s disease (AD) and consequent memory loss. Tau tangle aggregation in this …
Alzheimer9s disease (AD) and consequent memory loss. Tau tangle aggregation in this …
Brainstem substructures and cognition in prodromal Alzheimer's disease
Neuropathological research suggests the tau pathology of Alzheimer's disease may
originate in brainstem nuclei, yet it remains unknown whether tau-mediated degeneration of …
originate in brainstem nuclei, yet it remains unknown whether tau-mediated degeneration of …
Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia
HIL Jacobs, S Wiese, V van de Ven… - Neurobiology of …, 2015 - Elsevier
Neuropathology suggests an important role for the locus coeruleus (LC) in Alzheimer's
disease (AD) pathophysiology. Neuropathology and structural damage in the LC appears to …
disease (AD) pathophysiology. Neuropathology and structural damage in the LC appears to …
Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease
Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the
presence of brain pathology. A major open question is which brain mechanisms may …
presence of brain pathology. A major open question is which brain mechanisms may …