The proteasome is a multicatalytic enzyme expressed in all eukaryotic cells and responsible
for the degradation of polyubiquitinated proteins. Thereby, the proteasome regulates protein …

The immunoproteasome, a special class of the proteasome, is mainly expressed in cells of
haematopoietic origin. Additionally, during inflammation, the immunoproteasome is induced …

Numerous cellular processes are controlled by the proteasome, a multicatalytic protease in
the cytosol and nucleus of all eukaryotic cells, through regulated protein degradation. The …

The immunoproteasome generates peptides presented on MHC class I molecules to
cytotoxic T cells. ONX 0914 (formerly called PR-957) is a selective inhibitor of the …

The proteasome is a multicatalytic system involved in the degradation of polyubiquitinated
proteins. Thus, the proteasome is key to maintaining cell homeostasis. Stress and pro …

The proteasome, a large multisubunit protease complex, has been extensively investigated
over the years, greatly enhancing our understanding of critical roles that the proteasome …

Background and Purpose Multicatalytic endopeptidase complex‐like‐1 (β2i), low molecular
mass polypeptide (LMP) 2 (β1i) and LMP7 (β5i) are the proteolytically active subunits of the …

Proteasomes are large multi-subunit proteolytic complexes which are key components of the
ubiquitin-dependent protein degradation pathway. The constitutive proteasome is an isoform …

Selective inhibitors for the human immunoproteasome LMP7 (β5i) subunit over the
constitutive proteasome hold promise for the treatment of autoimmune and inflammatory …

Cells of hematopoietic origin express high levels of the immunoproteasome, a cytokine‐
inducible proteasome variant comprising the proteolytic subunits LMP2 (β1i), MECL‐1 (β2i) …