The immunoproteasome, known to play an important role in MHC class I antigen processing
and presentation, have been linked to neurodegenerative diseases and hematological …

The immunoproteasome is a variant of the 26S proteasome in which the catalytically active
standard β-subunits (β1c, β2c and β5c) are replaced by low molecular mass polypeptide …

The immunoproteasome is a highly efficient proteolytic machinery derived from the
constitutive proteasome and is abundantly expressed in immune cells. The …

The immunoproteasome, a distinct class of proteasomes, which is inducible under
inflammatory conditions and constitutively expressed in monocytes and lymphocytes, is …

Treatment of cells with interferon-γ leads to the replacement of the constitutive catalytic
proteasome subunits β1, β2, and β5 by the inducible subunits LMP2 (β1i), MECL-1 (β2i) …

In addition to antigen processing, immunoproteasomes were recently shown to exert
functions influencing cytokine production by monocytes and T cells, T‐helper cell …

Abstract Abstract 612 Background: Therapeutic targeting of Ubiquitin-Proteasome pathway
is exemplified by the recent FDA approval of dipeptidyl boronic acid bortezomib first-in-class …

Immunoproteasome is an emerging biological target that constitutes a key element not only
in antigen presentation but also in T cell and cytokine regulation as well as cellular …

Proteasomes are multisubunit proteases that initiate degradation of many Ags presented by
MHC class I molecules. Vertebrates express alternate forms of each of the three catalytic …

Immunoproteasome is a variant of proteasome with structural differences in 20S subunits
optimizing them for the production of antigenic peptides with higher binding affinity to major …