The ubiquitin-proteasome pathway is a well-characterized mechanism deputed to the
degradation of intracellular proteins. Proteasomal degradation intervenes in the regulation …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the
crystal structure of the murine immunoproteasome in complex with a selective inhibitor …

Immunoproteasomes comprise a specialized subset of proteasomes that is defined by the
presence of three catalytic immunosubunits: LMP2, MECL-1 (LMP10), and LMP7 …

The immunoproteasome subunit low molecular weight protein 2 (LMP2) codon 60
polymorphism has been associated with autoimmune diseases. It has also been …

Immunoproteasomes are a special class of proteasomes, which can be induced with IFN‐γ
in an inflammatory environment. In recent years, it became evident that certain immune cell …

The proteasome is the central component of the main cellular protein degradation pathway.
During the past four decades, the critical function of the proteasome in numerous …

The prime function of proteasomes is the control of protein homeostasis in cells (ie, the
removal of proteins that are not properly folded, damaged by stress conditions like reactive …

At the heart of the ubiquitin–proteasome system, the 20S proteasome core particle (CP)
breaks down the majority of intracellular proteins tagged for destruction. Thereby, the CP …

As the central figure of the cellular protein degradation machinery, the proteasome is critical
for cell survival. Having been extensively targeted for inhibition, the constitutive proteasome …