Background Angiogenesis plays an important role in the survival of tissues, as blood vessels
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …

Background Angiogenesis is important in physiological and pathological conditions, as
blood vessels provide nutrients and oxygen needed for tissue growth and survival …

Abstract Vascular Endothelial Growth Factor (VEGF) signal transduction is central to
angiogenesis in development and in pathological conditions such as cancer, retinopathy …

The transcriptional pathways activated downstream of vascular endothelial growth factor
(VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the …

The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated
kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK …

The formation of new blood vessel networks occurs via angiogenesis during development,
tissue repair, and disease. Angiogenesis is regulated by intracellular endothelial signalling …

Although it is appreciated that canonical signal‐transduction pathways represent dominant
modes of regulation embedded in larger interaction networks, relatively little has been done …

Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in
development and in pathological conditions such as cancer, retinopathy and ischemic …

The main treatment strategy for ischemic diseases caused by conditions such as poor blood
vessel formation or abnormal blood vessels involves repairing vascular damage and …

To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling
networks, we developed a simulation model of ERK signalling networks by constraining in …