ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
Background Angiogenesis plays an important role in the survival of tissues, as blood vessels
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …
provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is …
Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors
Background Angiogenesis is important in physiological and pathological conditions, as
blood vessels provide nutrients and oxygen needed for tissue growth and survival …
blood vessels provide nutrients and oxygen needed for tissue growth and survival …
Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking
WH Tan, AS Popel, F Mac Gabhann - Cellular signalling, 2013 - Elsevier
Abstract Vascular Endothelial Growth Factor (VEGF) signal transduction is central to
angiogenesis in development and in pathological conditions such as cancer, retinopathy …
angiogenesis in development and in pathological conditions such as cancer, retinopathy …
Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network
JE Fish, M Cantu Gutierrez, LT Dang… - …, 2017 - journals.biologists.com
The transcriptional pathways activated downstream of vascular endothelial growth factor
(VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the …
(VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the …
Integrin-mediated signalling through the MAP-kinase pathway
The mitogen activated protein (MAP) kinase cascade, leading to extracellular-regulated
kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK …
kinase (ERK) activation, is a key regulator of cell growth and proliferation. The effects of ERK …
Live-imaging of endothelial Erk activity reveals dynamic and sequential signalling events during regenerative angiogenesis
The formation of new blood vessel networks occurs via angiogenesis during development,
tissue repair, and disease. Angiogenesis is regulated by intracellular endothelial signalling …
tissue repair, and disease. Angiogenesis is regulated by intracellular endothelial signalling …
PI3K‐dependent cross‐talk interactions converge with Ras as quantifiable inputs integrated by Erk
Although it is appreciated that canonical signal‐transduction pathways represent dominant
modes of regulation embedded in larger interaction networks, relatively little has been done …
modes of regulation embedded in larger interaction networks, relatively little has been done …
Computational model of Gab1/2-dependent VEGFR2 pathway to Akt activation
WH Tan, AS Popel, F Mac Gabhann - PloS one, 2013 - journals.plos.org
Vascular endothelial growth factor (VEGF) signal transduction is central to angiogenesis in
development and in pathological conditions such as cancer, retinopathy and ischemic …
development and in pathological conditions such as cancer, retinopathy and ischemic …
The role of the ERK signaling pathway in promoting angiogenesis for treating ischemic diseases
YY Song, D Liang, DK Liu, L Lin, L Zhang… - Frontiers in Cell and …, 2023 - frontiersin.org
The main treatment strategy for ischemic diseases caused by conditions such as poor blood
vessel formation or abnormal blood vessels involves repairing vascular damage and …
vessel formation or abnormal blood vessels involves repairing vascular damage and …
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
To elucidate the hidden dynamics of extracellular-signal-regulated kinase (ERK) signalling
networks, we developed a simulation model of ERK signalling networks by constraining in …
networks, we developed a simulation model of ERK signalling networks by constraining in …