Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms

ZS Lima, M Ghadamzadeh, FT Arashloo… - Journal of hematology & …, 2019 - Springer
Breast cancer is the most common malignancy in women all over the world. Genetic
background of women contributes to her risk of having breast cancer. Certain inherited DNA …

Rapid detection of genetic mutations in individual breast cancer patients by next-generation DNA sequencing

S Liu, H Wang, L Zhang, C Tang, L Jones, H Ye, L Ban… - Human genomics, 2015 - Springer
Breast cancer is the most common malignancy in women and the leading cause of cancer
deaths in women worldwide. Breast cancers are heterogenous and exist in many different …

DNA mutations may not be the cause of cancer

A Adjiri - Oncology and therapy, 2017 - Springer
Cancer is the most challenging disease of our time with increasing numbers of new cases
each year, worldwide. Great achievements have been reached in cancer research through …

Deciphering and targeting oncogenic mutations and pathways in breast cancer

L Santarpia, G Bottai, CM Kelly, B Győrffy… - The …, 2016 - academic.oup.com
Advances in DNA and RNA sequencing revealed substantially greater genomic complexity
in breast cancer than simple models of a few driver mutations would suggest. Only very few …

Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments

U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

New drugs for breast cancer subtypes: targeting driver pathways to overcome resistance

G Curigliano - Cancer treatment reviews, 2012 - Elsevier
Breast cancer is not a single disease. Genetic array tools can define several subtypes.
Specific biological processes and distinct gene pathways are associated with prognosis and …

Breast cancer; discovery of novel diagnostic biomarkers, drug resistance, and therapeutic implications

S Afzal, M Hassan, S Ullah, H Abbas… - Frontiers in molecular …, 2022 - frontiersin.org
Breast cancer is the second most reported cancer in women with high mortality causing
millions of cancer-related deaths annually. Early detection of breast cancer intensifies the …

Translational genomics: practical applications of the genomic revolution in breast cancer

LR Yates, C Desmedt - Clinical Cancer Research, 2017 - AACR
The genomic revolution has fundamentally changed our perception of breast cancer. It is
now apparent from DNA-based massively parallel sequencing data that at the genomic …

Identifying breast cancer druggable oncogenic alterations: lessons learned and future targeted options

A Ocana, A Pandiella - Clinical Cancer Research, 2008 - AACR
Although the introduction of novel therapies and drug combinations has improved the
prognosis of metastatic breast cancer, this disease remains incurable. It is therefore …

Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

GT Lang, YZ Jiang, JX Shi, F Yang, XG Li… - Nature …, 2020 - nature.com
The remarkable advances in next-generation sequencing technology have enabled the
wide usage of sequencing as a clinical tool. To promote the advance of precision oncology …