Association of cognition and brain reserve in aging and glymphatic function using diffusion tensor image-along the perivascular space (DTI-ALPS)

WC Hsiao, HI Chang, SW Hsu, CC Lee, SH Huang… - Neuroscience, 2023 - Elsevier
The glymphatic system is a fluid-clearance pathway that clears cerebral waste products, and
its dysfunction has been associated with protein aggregation diseases such as Alzheimer's …

Glymphatic function plays a protective role in ageing-related cognitive decline

J Wang, Y Zhou, K Zhang, W Ran, X Zhu… - Age and …, 2023 - academic.oup.com
Objective The glymphatic pathway, characterised as a cerebral drainage system, influences
cognitive function in neurodegenerative diseases; however, evidence is limited in a normal …

Evaluation of glymphatic system activity using diffusion tensor image analysis along the perivascular space and amyloid PET in older adults with objectively normal …

CJ Park, SY Kim, JH Kim, NH Son, JY Park… - Frontiers in Aging …, 2023 - frontiersin.org
Objectives Diffusion tensor image analysis along the perivascular space (DTI-ALPS) is a
recently introduced method for the assessment of the glymphatic system without the need for …

Gray matter reserve determines glymphatic system function in young‐onset Alzheimer's disease: evidenced by DTI‐ALPS and compared with age‐matched controls

HI Chang, CW Huang, SW Hsu… - Psychiatry and …, 2023 - Wiley Online Library
Background The diffusion tensor imaging analysis along the perivascular space (ALPS)‐
index can be used to model the glymphatic system in vivo. Aim This study explores putative …

Glymphatic system impairment in Alzheimer's disease: associations with perivascular space volume and cognitive function

X Zhang, Y Wang, B Jiao, Z Wang, J Shi, Y Zhang… - European …, 2024 - Springer
Objectives To investigate glymphatic function in Alzheimer's disease (AD) using the diffusion
tensor image analysis along the perivascular space (DTI-ALPS) method and to explore the …

Assessment of the DTI‐ALPS parameter along the perivascular space in older adults at risk of dementia

CE Steward, VK Venkatraman, E Lui… - Journal of …, 2021 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE Recently, there has been growing interest in
the glymphatic system (the functional waste clearance pathway for the central nervous …

Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and Alzheimer disease

K Kamagata, C Andica, K Takabayashi, Y Saito… - Neurology, 2022 - AAN Enterprises
Background and Objectives The glymphatic system is a whole-brain perivascular network,
which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal …

Structural network efficiency mediates the association between glymphatic function and cognition in mild VCI: a DTI-ALPS study

H Song, Z Ruan, L Gao, D Lv, D Sun, Z Li… - Frontiers in Aging …, 2022 - frontiersin.org
Background and objective: Vascular cognitive impairment (VCI) can be caused by multiple
types of cerebrovascular pathology and is considered a network disconnection disorder. The …

The influence of demographics and vascular risk factors on glymphatic function measured by diffusion along perivascular space

Y Zhang, R Zhang, Y Ye, S Wang, Y Jiaerken… - Frontiers in Aging …, 2021 - frontiersin.org
Assessing glymphatic function using in-vivo imaging method is of great value for
understanding its contribution to major brain diseases. In the present study, we aim to …

The aging of glymphatic system in human brain and its correlation with brain charts and neuropsychological functioning

Z Dai, Z Yang, X Chen, W Zheng, Z Zhuang… - Cerebral …, 2023 - academic.oup.com
This study aimed to investigate the aging of the glymphatic system in healthy adults, and to
determine whether this change is correlated with the brain charts and neuropsychological …