Design and Synthesis of Some Novel Heterocyclic Compounds for Antithrombotic Activity
Design and Synthesis of Some Novel Heterocyclic Compounds for Antithrombotic Activity …

This paper describes the synthesis of orally available potent fXa inhibitors 2 and 3 by
modification of the piperazine part of lead compound 1. Carbonyl derivative 3 showed potent …

Abstract A series of pyrrolo [3, 2-d] pyrimidineone compounds have been designed and
synthesized as novel FXa inhibitors. Bioassay of the tested compounds showed moderate to …

Factor Xa (FXa) is well known to play a pivotal role in blood coagulation, so FXa inhibitor is a
promising drug candidate for prophylaxis and treatment of thromboembolic diseases. In the …

Direct inhibition of FXa has emerged as an effective strategy to achieve anticoagulation
maintaining normal hemostasis with minimal bleeding risks. A novel series of …

To develop a potent and oral anticoagulant, a series of compounds with cinnamyl moiety
was synthesized and their factor Xa (FXa) inhibitory activities were examined. As a result …

Abstract The coagulation factor Xa (FXa) plays a central role in the blood coagulation
cascade. Recent studies have shown that FXa is a particularly attractive target for the …

Compound YM-60828 was previously characterized in our laboratory as a potent, selective
and orally-bioavailable Factor Xa (FXa) inhibitor. The L-shape conformation of this …

Intravascular clot formation is an important event in a number of cardiovascular diseases.
The prevention of blood coagulation has become a major target for new therapeutic agents …

Thrombotic disorders like deep vein thrombosis, pulmonary embolism, myocardial infarction
and stroke, all are a major concern and one of the primary causes of mortality today …