Factor Xa (FXa) plays a significant role in the blood coagulation cascade and it has become
a promising target for anticoagulation drugs. Three oral direct FXa inhibitors have been …

A series of glycolic and mandelic acid derivatives was synthesized and investigated for their
factor Xa inhibitory activity. These analogues are highly potent and selective inhibitors …

Thienopyridine sulfonamide pyrrolidinones were found to be potent and selective inhibitors
of the coagulation cascade enzyme factor Xa. SAR studies led to several compounds that …

Abstract Coagulation factor Xa (FXa), a serine endopeptidase is a common coagulation
factor activated as a result of the initiation of both intrinsic and extrinsic blood coagulation …

A series of novel 2, 7-disubstituted tetrahydroisoquinoline derivatives were designed and
synthesized. Among these derivatives, compounds 1 and 2 (JTV-803) exhibited potent …

We previously reported on a series of cyclohexanediamine derivatives as highly potent
factor Xa inhibitors. Herein, we describe the modification of the spacer moiety to discover an …

Intravascular clot formation is an important factor in a number of cardiovascular diseases.
Therefore, the prevention of blood coagulation has become a major target for new …

A series of novel tetrahydropyrazolopyridone derivatives containing 1, 3, 4-triazole,
triazolylmethyl, and partially saturated heterocyclic moieties as P2 binding element was …

Direct oral anticoagulants are an important and relatively new class of synthetic
anticoagulant drugs commonly used for the pharmacotherapy of thromboembolic disorders …

Coagulation factor Xa (fXa) is a particularly attractive target for the development of effective
and safe anticoagulants. In this study, novel 2, 3-dihydroquinazolin-4 (1H)-one derivatives …