Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors -
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Structure and property based drug design was exploited in the synthesis of
sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups …

Structure-based drug design was exploited in the synthesis of 3-(6-chloronaphth-2-
ylsulfonyl) aminopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating an …

Recently, FXIIa was highlighted as an original attractive target for the development of new
anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe …

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets
for treatment for thrombotic disorders and thereby their inhibitors can serve as effective …

Despite extensive research in the field of thrombotic diseases, the prevention of blood clots
remains an important area of study. Therefore, the development of new anticoagulant drugs …

In our investigation of factor Xa inhibitors, a series of 1-(6-chloronaphthalen-2-yl) sulfonyl-4-
(4, 5, 6, 7-tetrahydrothiazolo [5, 4-c] pyridine-2-carbonyl) piperazines 3a–i were synthesized …

We describe here our investigation of a new series of orally active fXa inhibitors based on a
prodrug strategy. Solid-phase parallel synthesis identified a unique series of fXa inhibitors …

Factor Xa (FXa) is a trypsin-like serine protease that plays a key role in the blood
coagulation cascade. It holds a central position that links the intrinsic and extrinsic pathways …

Factor Xa is an important serine protease in the blood coagulation cascade. It generates
thrombin and holds the central position that links the intrinsic and extrinsic activation …