Research into the pathogenesis of Alzheimer's Disease (AD) has increased steadily over
recent years, with efforts focused on the differences between alterations of neural activity in …

Alzheimer's disease (AD), has been linked to abnormalities in several neurotransmitter and
neuropeptide systems. Central noradrenergic, serotonergic, somatostatinergic and CRF …

Publisher Summary This chapter describes the cholinergic system in Alzheimer disease
(AD). Choline acetyltransferase (ChAT), the synthetic enzyme for acetylcholine (ACh), is …

Although Alzheimer's disease (AD) is the most common form of senile dementia there is as
yet no effective therapy for this disorder. The most profound neuropathological changes …

The neurochemical pathology of Alzheimer's disease (AD) has been consistently shown to
involve cholinergic degeneration in the cerebral cortex. This together with evidence from …

Cerebrospinal fluid acetylcholinesterase (AChE) activity levels and choline (Ch) levels were
studied in 52 dementia of Alzheimer type (DAT) patients and 20 age‐matched controls. The …

Normal aging and Alzheimer's disease are characterized by similar morphological, chemical
and behavioral changes. These include cell loss, senile plaque formation, the presence of …

Alzheimer's disease (AD) is characterized by degeneration of neurons in several
neurotransmitter-specific systems (Price et al., in press; Whitehouse et al., in press b) …

Is acetylcholine (ACh) metabolism in brain reflected by changes in the cerebrospinal fluid
(CSF)? Are there specific changes in enzyme activities associated with ACh synthesis and …

Abstract Changes in the cholinergic, serotonergic, noradrenergic, dopaminergic, GABAergic
and somatostatinergic neurons were investigated to determine their roles in Alzheimer's …